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    A New Statistical Method for Dose-Finding Based on Efficacy and Toxicity in Early Phase Clinical Trials

    Most statistical methods for dose-finding in phase I clinical trials determine a maximum tolerable dose based on toxicity while ignoring efficacy. Most phase II designs assume that an acceptable dose has been ...

    Peter F. Thall, Elihu H. Estey, Hsi-Guang Sung in Investigational New Drugs (1999)