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Article
Impacts of shell structure on nitrate-reduction activity and air stability of nanoscale zero-valent iron
Nanoscale zero-valent iron (nZVI) has been intensively studied for pollution control because of its high reductive activity and environmental benignity, but the poor reaction selectivity and the aging problem ...
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Article
The distributions, contamination status, and health risk assessments of mercury and arsenic in the soils from the Yellow River Delta of China
The surface soils were collected from four areas in the Yellow River Delta (YRD), including three functional areas in the natural reserve of the YRD (the core area, buffer area, and experimental area) and a ne...
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Article
Polybrominated Diphenyl Ethers in Surface Soils from the Yellow River Delta Natural Reserve, China: Occurrence, Sources, and Potential Risk
A total of 39 lower brominated PBDE congeners in surface soils from the Yellow River Delta Natural Reserve (YRDNR) were analyzed in the present study. The total concentrations of PBDEs (ΣPBDEs) ranged from “no...
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Article
Occurrence and Potential Risk of Polychlorinated Biphenyls in Surface Soils from the Yellow River Delta Natural Reserve, China
A total of 28 PCB congeners were determined using gas chromatography-mass spectrometry (GC–MS) in 46 surface soils collected from the Yellow River Delta Natural Reserve (YRDNR) and its adjacent area, China. Th...
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Article
Open AccessDifferentiation of adult human retinal pigment epithelial cells into dopaminergic-like cells in vitro and in the recipient monkey brain
Cell therapy is proposed to be a potential treatment for Parkinson’s disease (PD). Although fetal retinal pigment epithelial (RPE) cells have been tested in trials for treating PD patients, controversy has bee...
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Article
Geochemistry of vanadium (V) in Chinese coals
Vanadium in coals may have potential environmental and economic impacts. However, comprehensive knowledge of the geochemistry of V in coals is lacking. In this study, abundances, distribution and modes of occurre...
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Article
A 59-year sedimentary record of metal pollution in the sediment core from the Huaihe River, Huainan, Anhui, China
An approximately 59-year (1955–2014) sedimentary record of metal elements (Cu, Pb, Zn, Ni, Co, Mn, and Fe) in a sediment core, collected from the Huaihe River, Huainan City, Anhui Province, China, was reconstr...
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Article
Open AccessLong non-coding RNA GAS5 controls human embryonic stem cell self-renewal by maintaining NODAL signalling
Long non-coding RNAs (lncRNAs) are known players in the regulatory circuitry of the self-renewal in human embryonic stem cells (hESCs). However, most hESC-specific lncRNAs remain uncharacterized. Here we demon...
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Article
Fractional distribution and risk assessment of heavy metals in sediments collected from the Yellow River, China
Bohai Sea is one of the most intensively exploited region in the world and its environment has been severely impacted by the extensive human activities. The Yellow River is the most important river which conne...
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Article
Open AccessInduction of site-specific chromosomal translocations in embryonic stem cells by CRISPR/Cas9
Chromosomal translocation is the most common form of chromosomal abnormality and is often associated with congenital genetic disorders, infertility and cancers. The lack of cellular and animal models for chrom...
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Article
Metal distribution and bioavailability in surface sediments from the Huaihe River, Anhui, China
This study presents the total concentrations and chemical fractionations of metals (Cu, Pb, Zn, Ni, Fe, and Mn) in 54 surface sediment samples collected from the Huaihe River (Anhui Province) in eastern China....
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Article
RNA interference mediated JAM-A gene silencing promotes human epidermal stem cell proliferation
The objective of the study was to explore the influence of junctional adhesion molecule A (JAM-A) gene decoration on proliferation and differentiation of human epidermal stem cells (hEpSCs). JAM-A gene and JAM...
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Article
Occurrence, Sources, and Potential Toxicity of Polycyclic Aromatic Hydrocarbons in Surface Soils from the Yellow River Delta Natural Reserve, China
A total of 46 surface soil samples collected from the experimental area, buffer area, and core area of the Yellow River Delta Natural Reserve (YRDNR), China, and an adjacent area outside the reserve were anal...
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Article
Mir-218 contributes to the transformation of 5-Aza/GF induced umbilical cord mesenchymal stem cells into hematopoietic cells through the MITF pathway
Experiments with 5′-azacytidine and hematopoietic growth factor approved for the transformation of human mesenchymal cells into hematopoietic cells have demonstrated that cell fate can be dramatically altered...
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Article
Directed differentiation of aged human bone marrow multipotent stem cells effectively generates dopamine neurons
This study aimed to isolate aged human bone marrow multipotent stem cells (hAMSCs) with the potential for multilineage differentiation and to directly induce the cells to generate dopamine neurons, which could...
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Article
Epidermal growth factor promotes transforming growth factor-β1-induced epithelial-mesenchymal transition in HK-2 cells through a synergistic effect on Snail
Epithelial-mesenchymal transition (EMT) is a central mechanism for wound healing, tissue repair, organ fibrosis and carcinoma progression in adults. Evidence shows that both epidermal growth factor (EGF) and t...
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Article
Open AccessNeural stem cell-like cells derived from autologous bone mesenchymal stem cells for the treatment of patients with cerebral palsy
Stem cell therapy is a promising treatment for cerebral palsy, which refers to a category of brain diseases that are associated with chronic motor disability in children. Autologous MSCs may be a better cell s...
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Article
microRNA-29b is a novel mediator of Sox2 function in the regulation of somatic cell reprogramming
Fibroblasts can be reprogrammed into induced pluripotent stem cells (iPSCs) by the application of Yamanaka factors (OSKM), but the mechanisms underlying this reprogramming remain poorly understood. Here, we re...
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Article
Differentiation of human adipose-derived stem cells induced by recombinantly expressed fibroblast growth factor 10 in vitro and in vivo
The adipogenesis effect of fibroblast growth factor 10 (FGF10) has been demonstrated in many studies. The aim of this study is to render a novel method which can continuously induce hypodermal adipose-derived ...
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Article
Human embryonic germ cells isolation from early stages of post-implantation embryos
Human embryonic germ (hEG) cell is a very important alternative pluripotent stem cell resource. We describe the derivation of hEG cells from human embryonic fetal gonads over 6–8 weeks postconception. A large ...
