-
Article
Open AccessDifferentiation of adult human retinal pigment epithelial cells into dopaminergic-like cells in vitro and in the recipient monkey brain
Cell therapy is proposed to be a potential treatment for Parkinson’s disease (PD). Although fetal retinal pigment epithelial (RPE) cells have been tested in trials for treating PD patients, controversy has bee...
-
Article
Open AccessLong non-coding RNA GAS5 controls human embryonic stem cell self-renewal by maintaining NODAL signalling
Long non-coding RNAs (lncRNAs) are known players in the regulatory circuitry of the self-renewal in human embryonic stem cells (hESCs). However, most hESC-specific lncRNAs remain uncharacterized. Here we demon...
-
Article
Open AccessInduction of site-specific chromosomal translocations in embryonic stem cells by CRISPR/Cas9
Chromosomal translocation is the most common form of chromosomal abnormality and is often associated with congenital genetic disorders, infertility and cancers. The lack of cellular and animal models for chrom...
-
Article
Open AccessNeural stem cell-like cells derived from autologous bone mesenchymal stem cells for the treatment of patients with cerebral palsy
Stem cell therapy is a promising treatment for cerebral palsy, which refers to a category of brain diseases that are associated with chronic motor disability in children. Autologous MSCs may be a better cell s...
-
Article
microRNA-29b is a novel mediator of Sox2 function in the regulation of somatic cell reprogramming
Fibroblasts can be reprogrammed into induced pluripotent stem cells (iPSCs) by the application of Yamanaka factors (OSKM), but the mechanisms underlying this reprogramming remain poorly understood. Here, we re...
