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Article
Open AccessLong non-coding RNA GAS5 controls human embryonic stem cell self-renewal by maintaining NODAL signalling
Long non-coding RNAs (lncRNAs) are known players in the regulatory circuitry of the self-renewal in human embryonic stem cells (hESCs). However, most hESC-specific lncRNAs remain uncharacterized. Here we demon...
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Article
Open AccessInduction of site-specific chromosomal translocations in embryonic stem cells by CRISPR/Cas9
Chromosomal translocation is the most common form of chromosomal abnormality and is often associated with congenital genetic disorders, infertility and cancers. The lack of cellular and animal models for chrom...