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Article
Open AccessRetraction Note: LncRNA PCAT6 regulates the progression of pituitary adenomas by regulating the miR-139-3p/BRD4 axis
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Article
Open AccessNatural evidence of coronaviral 2′-O-methyltransferase activity affecting viral pathogenesis via improved substrate RNA binding
Previous studies through targeted mutagenesis of K-D-K-E motif have demonstrated that 2′-O-MTase activity is essential for efficient viral replication and immune evasion. However, the K-D-K-E catalytic motif o...
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Article
Open AccessImprovement of roughness in ultrasonic assisted magnetorheological finishing of small titanium alloy nuts by orthogonal test method
Titanium alloy with high corrosion resistance, high strength-to-density ratio, and excellent biocompatibility has a wide range of applications in the field of biomedical implants. Polishing experiments of tita...
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Article
Danlou Tablet Protects Against Myocardial Infarction Through Promoting eNOS-Dependent Endothelial Protection and Angiogenesis
Myocardial infarction (MI) is one of the leading causes of death worldwide. Danlou tablet (Dan) is an effective traditional Chinese medicine for cardiac protection, although the underlying mechanism was not fu...
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Article
Deficiency of N6-Methyladenosine Demethylase ALKBH5 Alleviates Ultraviolet B Radiation-Induced Chronic Actinic Dermatitis via Regulating Pyroptosis
Pyroptosis is an inflammatory programmed cell death (PCD) and is reported to be associated with N6-methyladenosine (m6A) modification. This study aimed to investigate the mechanism of m6A demethylase AlkB homo...
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Article
Open AccessMagnetic circuit design for the performance experiment of shear yield stress enhanced by compression of magnetorheological fluids
The shear yield stress is an important parameter for the industrial application of magnetorheological (MR) fluids. A test equipment was designed and built to perform investigations on the behaviours of compres...
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Article
Open AccessIsoelectronic aluminum-doped gallium nitride alpha-voltaic cell with efficiency exceeding 4.5%
Although alpha-voltaic cells have shown great potential in unattended miniaturized systems for compact, long-lifetime and independence of external energy input, the power conversion efficiency of state-of the-...
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Article
Chitinase 3-like 1: a Specifical Regulator of Myocardial Infarction
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Article
Open AccessCZK, a novel alkaloid derivative from Clausena lansium, alleviates ischemic stroke injury through Nrf2-mediated antioxidant effects
Anti-oxidant stress is a potential strategy for the treatment of ischemic stroke. Here, we found a novel free radical scavenger termed as CZK, which is derived from alkaloids contained in Clausena lansium. In thi...
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Article
Antioxidants Supplementation During Exercise: Friends or Enemies for Cardiovascular Homeostasis?
Exercise is a preferred strategy for improving cardiac function, especially for patients with cardiovascular diseases. Increasing evidence indicates that oxidative stress is involved in exercise-induced cardio...
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Updated Methods of Extracellular Vesicles Isolation
Extracellular vesicles (EVs) are considered as cargo and mediate intercellular communication. As natural biological nanoparticles, EVs can be secreted by almost all kinds of cells and exist in biofluids such a...
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Article
Open AccessDimethylarginine dimethylaminohydrolase 1 protects PM2.5 exposure-induced lung injury in mice by repressing inflammation and oxidative stress
Airborne fine particulate matter with aerodynamic diameter ≤ 2.5 μm (PM2.5) pollution is associated with the prevalence of respiratory diseases, including asthma, bronchitis and chronic obstructive pulmonary dise...
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Article
Open AccessThe intestinal flora of patients with GHPA affects the growth and the expression of PD-L1 of tumor
Pituitary adenoma (PA) is a common intracranial tumor. The evidence indicates that the tumor immune microenvironment (TIME) is associated with PA and that the intestinal flora influences other tumors' growth t...
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Article
In Silico Modeling and Simulation to Guide Bioequivalence Testing for Oral Drugs in a Virtual Population
Model-informed drug discovery and development (MID3) shows great advantages in facilitating drug development. A physiologically based pharmacokinetic model is one of the powerful computational approaches of MI...
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Article
Up-regulation of the expressions of MiR-149-5p and MiR-99a-3p in exosome inhibits the progress of pituitary adenomas
This study explored the function of microRNAs (miRNAs) in invasive pituitary adenomas (IPA), and developed a microRNA-exosome strategy for the disease treatment. Differentially expressed miRNAs and tumor-assoc...
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Article
Open AccessTransient behavior of compressed magnetorheological brake excited by step currents
Transient behavior of a magnetorheological brake excited by step currents under compression-shear mode has been experimentally studied. The results show that the amplitude of the applied current had little eff...
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Article
Open AccessCompressions of magnetorheological fluids under instantaneous magnetic field and constant area
Compressions of magnetorheological (MR) fluids have been carried out under instantaneous magnetic fields. The yield strength of the MR fluid in compressive mode has been derived by assuming that it was a trans...
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Article
Open AccessTargets identified from exercised heart: killing multiple birds with one stone
Cardiovascular diseases (CVDs) are a major cause of mortality worldwide, which are mainly driven by factors such as aging, sedentary lifestyle, and excess alcohol use. Exercise targets several molecules and pr...
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Article
A phase 1 pharmacokinetic study of oral NEPA, the fixed combination of netupitant and palonosetron, in Chinese healthy volunteers
Oral NEPA, the only fixed-combination antiemetic, is composed of the neurokinin-1 receptor antagonist netupitant (300 mg) and the 5-hydroxytryptamine-3 receptor antagonist palonosetron (0.50 mg). This study wa...
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Article
Open AccessSHP2 blockade enhances anti-tumor immunity via tumor cell intrinsic and extrinsic mechanisms
SHP2 is a ubiquitous tyrosine phosphatase involved in regulating both tumor and immune cell signaling. In this study, we discovered a novel immune modulatory function of SHP2. Targeting this protein with allos...
