![Loading...](https://link.springer.com/static/c4a417b97a76cc2980e3c25e2271af3129e08bbe/images/pdf-preview/spacer.gif)
357 Result(s)
-
Article
Open AccessEnhancing efficiency of protein language models with minimal wet-lab data through few-shot learning
Accurately modeling the protein fitness landscapes holds great importance for protein engineering. Pre-trained protein language models have achieved state-of-the-art performance in predicting protein fitness w...
-
Article
Open AccessCloud inversion analysis of surrounding rock parameters for underground powerhouse based on PSO-BP optimized neural network and web technology
Aiming at the shortcomings of the BP neural network in practical applications, such as easy to fall into local extremum and slow convergence speed, we optimized the initial weights and thresholds of the BP neu...
-
Article
Open AccessAnalytical and experimental analysis of concrete temperature and energy considering open-air environmental variations
Longwave radiation is an important open-air environmental factor that can significantly affect the temperature of concrete, but it has often been ignored in the temperature analysis of open-air concrete struct...
-
Article
Open AccessMulti-cohort analysis reveals immune subtypes and predictive biomarkers in tuberculosis
Tuberculosis (TB) remains a significant global health threat, necessitating effective strategies for diagnosis, prognosis, and treatment. This study employs a multi-cohort analysis approach to unravel the immu...
-
Article
Open AccessMachine learning-guided realization of full-color high-quantum-yield carbon quantum dots
Carbon quantum dots (CQDs) have versatile applications in luminescence, whereas identifying optimal synthesis conditions has been challenging due to numerous synthesis parameters and multiple desired outcomes,...
-
Article
Open AccessCu(II)-based complex loaded with drug paclitaxel hydrogels against thyroid cancer and optimizing novel derivatives
This study introduces a novel approach for synthesizing a Cu(II)-based coordination polymer (CP), {[Cu(L)(4,4´-OBA)]·H2O}n (1), using a mixed ligand method. The CP was successfully prepared by reacting Cu(NO3)2·3...
-
Article
Imaging surface structure and premelting of ice Ih with atomic resolution
Ice surfaces are closely relevant to many physical and chemical properties, such as melting, freezing, friction, gas uptake and atmospheric reaction1–8. Despite extensive experimental and theoretical investigatio...
-
Article
Open AccessCapture of single Ag atoms through high-temperature-induced crystal plane reconstruction
The “terminal hydroxyl group anchoring mechanism” has been studied on metal oxides (Al2O3, CeO2) as well as a variety of noble and transition metals (Ag, Pt, Pd, Cu, Ni, Fe, Mn, and Co) in a number of generalized...
-
Article
Open AccessAssociation between exposure to ambient air pollution, meteorological factors and atopic dermatitis consultations in Singapore—a stratified nationwide time-series analysis
Atopic dermatitis (AD) is a chronic inflammatory skin disease affecting approximately 20% of children globally. While studies have been conducted elsewhere, air pollution and weather variability is not well st...
-
Article
Long-range order enabled stability in quantum dot light-emitting diodes
Light-emitting diodes (LEDs) based on perovskite quantum dots (QDs) have produced external quantum efficiencies (EQEs) of more than 25% with narrowband emission1,2, but these LEDs have limited operating lifetimes...
-
Article
Open AccessAn artificial visual neuron with multiplexed rate and time-to-first-spike coding
Human visual neurons rely on event-driven, energy-efficient spikes for communication, while silicon image sensors do not. The energy-budget mismatch between biological systems and machine vision technology has...
-
Article
Open AccessUpgrading CO2 to sustainable aromatics via perovskite-mediated tandem catalysis
The directional transformation of carbon dioxide (CO2) with renewable hydrogen into specific carbon-heavy products (C6+) of high value presents a sustainable route for net-zero chemical manufacture. However, it i...
-
Article
Open AccessAdvancing high-performance visible light communication with long-wavelength InGaN-based micro-LEDs
This study showcases a method for achieving high-performance yellow and red micro-LEDs through precise control of indium content within quantum wells. By employing a hybrid quantum well structure with our six ...
-
Article
Open AccessPredictive evolutionary modelling for influenza virus by site-based dynamics of mutations
Influenza virus continuously evolves to escape human adaptive immunity and generates seasonal epidemics. Therefore, influenza vaccine strains need to be updated annually for the upcoming flu season to ensure v...
-
Article
Open AccessNeoadjuvant–adjuvant pertuzumab in HER2-positive early breast cancer: final analysis of the randomized phase III PEONY trial
The randomized, multicenter, double-blind, placebo-controlled, phase III PEONY trial (NCT02586025) demonstrated significantly improved total pathologic complete response (primary endpoint) with dual HER2 block...
-
Article
Open AccessMulticenter study of seasonal and regional airborne allergens in Chinese preschoolers with allergic rhinitis
This study is nationwide multicenter epidemiological research, aimed at investigating the distribution changes and seasonal patterns of various airborne allergens among preschool children with allergic rhiniti...
-
Article
Open AccessOcular microvascular alteration in patients with myocardial infarction—a new OCTA study
Myocardial infarction is defined as a sudden decrease or interruption in blood flow to the coronary arteries, causing ischemic necrosis of the corresponding cardiomyocytes. It is unclear whether systemic macro...
-
Article
Open AccessHarmonic amide bond density as a game-changer for deciphering the crosslinking puzzle of polyamide
It is particularly essential to analyze the complex crosslinked networks within polyamide membranes and their correlation with separation efficiency for the insightful tailoring of desalination membranes. Howe...
-
Article
Open AccessContinuous and discontinuous compressible flows in a converging–diverging channel solved by physics-informed neural networks without exogenous data
Physics-informed neural networks (PINNs) are employed to solve the classical compressible flow problem in a converging–diverging nozzle. This problem represents a typical example described by the Euler equatio...
-
Article
Flexible silicon solar cells with high power-to-weight ratios
Silicon solar cells are a mainstay of commercialized photovoltaics, and further improving the power conversion efficiency of large-area and flexible cells remains an important research objective1,2. Here we repor...