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Article
Open AccessHigh levels of childhood trauma associated with changes in hippocampal functional activity and connectivity in young adults during novelty salience
Childhood trauma (CT) has been linked to increased risk for psychosis. Moreover, CT has been linked to psychosis phenotypes such as impaired cognitive and sensory functions involved in the detection of novel s...
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Article
Open AccessBrain distribution of dipeptide repeat proteins in frontotemporal lobar degeneration and motor neurone disease associated with expansions in C9ORF72
A hexanucleotide (GGGGCC) expansion in C9ORF72 gene is the most common genetic change seen in familial Frontotemporal Lobar Degeneration (FTLD) and familial Motor Neurone Disease (MND). Pathologically, expansion ...
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Article
Gata-3 is an essential regulator of mammary-gland morphogenesis and luminal-cell differentiation
The transcription factor Gata-3 is a defining marker of the 'luminal' subtypes of breast cancer1,2,3,4. To gain insight into the role of Gata-3 in breast epithelial development and oncogenesis, we have explored i...