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Article
Quantity of HLA-C surface expression and licensing of KIR2DL+ natural killer cells
Natural killer (NK) cells require interaction of inhibitory surface receptors with human leukocyte antigen (HLA) ligands during development to acquire functi...
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Article
Morphine Inhibited the Rat Neural Stem Cell Proliferation Rate by Increasing Neuro Steroid Genesis
Up to present, a large number of reports unveiled exacerbating effects of both long- and short-term administration of morphine, as a potent analgesic agent, on opium-addicted individuals and a plethora of cell...
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Article
Recent advances in electrochemical and electrochemiluminescence based determination of the activity of caspase-3
Caspases, especially caspase-3, play a critical role in the intrinsic and extrinsic pathways of apoptosis. In addition, caspase-3 is involved in mental disorders like Alzheimer disease. Any up and down regulat...
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Article
Advances in nanomaterial based optical biosensing and bioimaging of apoptosis via caspase-3 activity: a review
Caspase-3 plays a vital role in intrinsic and extrinsic pathways of programed cell death and in cell proliferation. Its detection is an important tool for early detection of some cancers and apoptosis-related ...
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Article
Regulation and modulation of PTEN activity
PTEN (Phosphatase and tensin homolog deleted on chromosome ten) is a tumor suppressor that is frequently mutated in most human cancers. PTEN is a lipid and protein phosphatase that antagonizes PI3K/AKT pathway...
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Article
Open AccessDietary protein sources and tumoral overexpression of RhoA, VEGF-A and VEGFR2 genes among breast cancer patients
High protein intake may promote angiogenesis giving support to the development of metastasis according to the experimental data. However, nutritional epidemiologic evidence is inconsistent with metastasis. The...
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Article
Open AccessProfiling the expression of pro-metastatic genes in association with the clinicopathological features of primary breast cancer
Metastasis accounts for ninety percent of breast cancer (BrCa) mortality. Cortactin, Ras homologous gene family member A (RhoA), and Rho-associated kinase (ROCK) raise cellular motility in favor of metastasis....
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Article
Performance evaluation of a novel conceptual bioprocess for clinically-required mass production of hematopoietic cells
The novel engineered bioprocess, which was designed and modeled to provide the clinically relevant cell numbers for different therapies in our previous work (Kaleybar et al. Food Bioprod Process 122:254–268, ...
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Article
The role of IL-12 in stimulating NK cells against Toxoplasma gondii infection: a mini-review
Toxoplasma gondii is an intracellular protozoan parasite that can remarkably infect, survive, and replicate in almost all mammalian cells and can cause severe neurological and ocular damage in immunocompromised i...
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Article
Cord blood derived NK cells activated in counter with tumor cells
NK cells are initially known for their ability to kill tumor cells with no prior sensitization. Production of mature and long lasting NK cells from Umbilical Cord Blood (UCB) by using cytokines could be a prom...