4 Result(s)
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Ho Min Kim
Biomedicine
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Article
Open AccessCrystal structure of LRG1 and the functional significance of LRG1 glycan for LPHN2 activation
The serum glycoprotein leucine-rich ɑ-2-glycoprotein 1 (LRG1), primarily produced by hepatocytes and neutrophils, is a multifunctional protein that modulates various signaling cascades, mainly TGFβ signaling. ...
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Article
Open AccessLatrophilin-2 is a novel receptor of LRG1 that rescues vascular and neurological abnormalities and restores diabetic erectile function
Diabetes mellitus (DM) is a chronic metabolic disorder characterized by inappropriate hyperglycemia, which causes endothelial dysfunction and peripheral neuropathy, ultimately leading to multiple complications...
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Article
Open AccessNeural circuit analysis using a novel intersectional split intein-mediated split-Cre recombinase system
The defining features of a neuron are its functional and anatomical connections with thousands of other neurons in the brain. Together, these neurons form functional networks that direct animal behavior. Curre...
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Article
Brain somatic mutations in MTOR cause focal cortical dysplasia type II leading to intractable epilepsy
Deep sequencing identifies somatic activating mutations of MTOR in affected brain regions of FCDII patients that are sufficient to cause neuronal migration defects and epileptic seizures in mice.
