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Article
Open AccessAge-dependent contribution of intrinsic mechanisms to sinoatrial node function in humans
Average beat interval (BI) and beat interval variability (BIV) are primarily determined by mutual entrainment between the autonomic-nervous system (ANS) and intrinsic mechanisms that govern sinoatrial node (SA...
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Article
Open AccessArtificial intelligence for the detection of COVID-19 pneumonia on chest CT using multinational datasets
Chest CT is emerging as a valuable diagnostic tool for clinical management of COVID-19 associated lung disease. Artificial intelligence (AI) has the potential to aid in rapid evaluation of CT scans for differe...
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Article
Open AccessErratum: Precise genome-wide base editing by the CRISPR Nickase system in yeast
A correction to this Article has been published and is linked from the HTML version of this paper. The error has been fixed in the paper.
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Article
Open AccessPrecise genome-wide base editing by the CRISPR Nickase system in yeast
The CRISPR/Cas9 system has been applied to efficient genome editing in many eukaryotic cells. However, the bases that can be edited by this system have been limited to those within the protospacer adjacent mot...
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Article
Open AccessHeterologous Production of the Marine Myxobacterial Antibiotic Haliangicin and Its Unnatural Analogues Generated by Engineering of the Biochemical Pathway
Despite their fastidious nature, marine myxobacteria have considerable genetic potential to produce novel secondary metabolites. The marine myxobacterium Haliangium ochraceum SMP-2 produces the antifungal polyket...
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Article
The ethylene response factors SNORKEL1 and SNORKEL2 allow rice to adapt to deep water
Monsoon season floods in Asia can cause widespread devastation of rice crops. Some strains of rice have adapted to this environmental stress by develo** the ability to undergo rapid stem elongation. Normally...