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Article
Open AccessTolerable glycometabolic stress boosts cancer cell resilience through altered N-glycosylation and Notch signaling activation
Chronic metabolic stress paradoxically elicits pro-tumorigenic signals that facilitate cancer stem cell (CSC) development. Therefore, elucidating the metabolic sensing and signaling mechanisms governing cancer...
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Article
Simultaneous and sialic acid linkage-specific N- and O-linked glycan analysis by ester-to-amide derivatization
Characterization of O-glycans linked to serine or threonine residues in glycoproteins has mostly been achieved using chemical reaction approaches because there are no known O-glycan-specific endoglycosidases. Mos...
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Protocol
Comprehensive Glycan Analysis of Sphingolipids in Human Serum/Plasma
Glycosphingolipids (GSLs) are glycolipids with ceramide and carbohydrate head groups that play an important role in numerous biological processes. Previously, we performed GSL-glycan analysis of various cell l...
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Protocol
Comprehensive and Comparative Structural Glycome Analysis in Mouse Epiblast-like Cells
Glycosylation is one of the most abundant posttranslational modifications and is involved in a wide range of cellular processes. Glycome diversity in mammals is generated by the action of over 200 distinct gly...