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  1. Article

    Open Access

    Tolerable glycometabolic stress boosts cancer cell resilience through altered N-glycosylation and Notch signaling activation

    Chronic metabolic stress paradoxically elicits pro-tumorigenic signals that facilitate cancer stem cell (CSC) development. Therefore, elucidating the metabolic sensing and signaling mechanisms governing cancer...

    Shungo Iwamoto, Takashi Kobayashi, Hisatoshi Hanamatsu in Cell Death & Disease (2024)

  2. No Access

    Article

    Simultaneous and sialic acid linkage-specific N- and O-linked glycan analysis by ester-to-amide derivatization

    Characterization of O-glycans linked to serine or threonine residues in glycoproteins has mostly been achieved using chemical reaction approaches because there are no known O-glycan-specific endoglycosidases. Mos...

    Hisatoshi Hanamatsu, Yoshiaki Miura, Takashi Nishikaze in Glycoconjugate Journal (2023)

  3. No Access

    Protocol

    Comprehensive Glycan Analysis of Sphingolipids in Human Serum/Plasma

    Glycosphingolipids (GSLs) are glycolipids with ceramide and carbohydrate head groups that play an important role in numerous biological processes. Previously, we performed GSL-glycan analysis of various cell l...

    Hisatoshi Hanamatsu, Takashi Nishikaze, Jun-ichi Furukawa in Glycolipids (2023)

  4. No Access

    Protocol

    Comprehensive and Comparative Structural Glycome Analysis in Mouse Epiblast-like Cells

    Glycosylation is one of the most abundant posttranslational modifications and is involved in a wide range of cellular processes. Glycome diversity in mammals is generated by the action of over 200 distinct gly...

    Federico Pecori, Hisatoshi Hanamatsu, Jun-ichi Furukawa in Epiblast Stem Cells (2022)