12 Result(s)
within
Hiroto Kuwabara
Neurosciences
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Article
Relationships Among Ventral Striatal Dopamine Release, Cortisol Secretion, and Subjective Responses to Amphetamine
There is evidence that stress and glucocorticoids alter drug self-administration and mesolimbic dopamine (DA) activity in preclinical models. The primary purpose of this study was to test the hypothesis that g...
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Dose effects of triazolam on brain activity during episodic memory encoding: a PET study
Although it is well established that acute benzodiazepine administration impairs episodic memory encoding, little is known about the neuroanatomical substrates of this effect.
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Article
Increased Occupancy of Dopamine Receptors in Human Striatum during Cue-Elicited Cocaine Craving
In all, 19 research subjects, with current histories of frequent cocaine use, were exposed to cocaine-related cues to elicit drug craving. We measured the change of occupancy of dopamine at D2-like receptors w...
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Article
Erratum: Increased Occupancy of Dopamine Receptors in Human Striatum during Cue-Elicited Cocaine Craving
Correction to: Neuropsychopharmacology (2006) 31, 2714–2725. doi:10.1038/sj.npp.1301194 Following the publication of this article, the authors noted that the author names were incomplete. The complete and corr...
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Article
Association of Amphetamine-Induced Striatal Dopamine Release and Cortisol Responses to Psychological Stress
Preclinical studies have shown that stress and glucocorticoids increase mesolimbic dopamine (DA) and thereby facilitate psychostimulant self-administration. The relationship between stress-induced cortisol and...
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Article
White Matter Correlates of Cognitive Capacity Studied With Diffusion Tensor Imaging: Implications for Cognitive Reserve
Cognitive reserve (CR) is a theoretical concept used to explain and study individual differences in cognitive symptom expression in neurological disease. In the absence of neurologic injury or demands on proce...
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Mechanisms of Dopaminergic and Serotonergic Neurotransmission in Tourette Syndrome: Clues from an In Vivo Neurochemistry Study with PET
Tourette syndrome (TS) is a neuropsychiatric disorder with childhood onset characterized by motor and phonic tics. Obsessive-compulsive disorder (OCD) is often concomitant with TS. Dysfunctional tonic and phas...
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Increased Cerebral Oxygen Metabolism and Ischemic Stress in Subjects with Metabolic Syndrome-Associated Risk Factors: Preliminary Observations
Hypertension, diabetes, obesity, and dyslipidemia are risk factors that characterize metabolic syndrome (MetS), which increases the risk for stroke by 40%. In a preliminary study, our aim was to evaluate cereb...
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Article
Determination of dopamine D2 receptor occupancy by lurasidone using positron emission tomography in healthy male subjects
A positron emission tomography (PET) study of dopamine D2 receptor occupancy was conducted to support a rational dose selection for clinical efficacy studies with lurasidone, an atypical antipsychotic that was ap...
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Article
History of childhood adversity is positively associated with ventral striatal dopamine responses to amphetamine
Childhood exposure to severe or chronic trauma is an important risk factor for the later development of adult mental health problems, such as substance abuse. Even in nonclinical samples of healthy adults, per...
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Article
Open AccessMetabotropic glutamate receptor 5 tracer [18F]-FPEB displays increased binding potential in postcentral gyrus and cerebellum of male individuals with autism: a pilot PET study
Autism is a neurodevelopmental disorder that is first manifested during early childhood. Postmortem experiments have identified significantly elevated expression of metabotropic glutamate receptor 5 (mGluR5) i...
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Open AccessPositron emission tomography imaging of serotonin degeneration and beta-amyloid deposition in late-life depression evaluated with multi-modal partial least squares
Depression in late-life is associated with increased risk of cognitive decline and development of all-cause dementia. The neurobiology of late-life depression (LLD) may involve both neurochemical and neurodege...
