7 Result(s)
within
Hiroto Kuwabara
Neurosciences
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Article
Open AccessPositron emission tomography imaging of serotonin degeneration and beta-amyloid deposition in late-life depression evaluated with multi-modal partial least squares
Depression in late-life is associated with increased risk of cognitive decline and development of all-cause dementia. The neurobiology of late-life depression (LLD) may involve both neurochemical and neurodege...
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Article
Open AccessMetabotropic glutamate receptor 5 tracer [18F]-FPEB displays increased binding potential in postcentral gyrus and cerebellum of male individuals with autism: a pilot PET study
Autism is a neurodevelopmental disorder that is first manifested during early childhood. Postmortem experiments have identified significantly elevated expression of metabotropic glutamate receptor 5 (mGluR5) i...
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Article
Mechanisms of Dopaminergic and Serotonergic Neurotransmission in Tourette Syndrome: Clues from an In Vivo Neurochemistry Study with PET
Tourette syndrome (TS) is a neuropsychiatric disorder with childhood onset characterized by motor and phonic tics. Obsessive-compulsive disorder (OCD) is often concomitant with TS. Dysfunctional tonic and phas...
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Article
Association of Amphetamine-Induced Striatal Dopamine Release and Cortisol Responses to Psychological Stress
Preclinical studies have shown that stress and glucocorticoids increase mesolimbic dopamine (DA) and thereby facilitate psychostimulant self-administration. The relationship between stress-induced cortisol and...
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Article
Erratum: Increased Occupancy of Dopamine Receptors in Human Striatum during Cue-Elicited Cocaine Craving
Correction to: Neuropsychopharmacology (2006) 31, 2714–2725. doi:10.1038/sj.npp.1301194 Following the publication of this article, the authors noted that the author names were incomplete. The complete and corr...
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Article
Increased Occupancy of Dopamine Receptors in Human Striatum during Cue-Elicited Cocaine Craving
In all, 19 research subjects, with current histories of frequent cocaine use, were exposed to cocaine-related cues to elicit drug craving. We measured the change of occupancy of dopamine at D2-like receptors w...
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Article
Relationships Among Ventral Striatal Dopamine Release, Cortisol Secretion, and Subjective Responses to Amphetamine
There is evidence that stress and glucocorticoids alter drug self-administration and mesolimbic dopamine (DA) activity in preclinical models. The primary purpose of this study was to test the hypothesis that g...
