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    Article

    History of childhood adversity is positively associated with ventral striatal dopamine responses to amphetamine

    Childhood exposure to severe or chronic trauma is an important risk factor for the later development of adult mental health problems, such as substance abuse. Even in nonclinical samples of healthy adults, per...

    Lynn M. Oswald, Gary S. Wand, Hiroto Kuwabara, Dean F. Wong… in Psychopharmacology (2014)

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    Article

    Determination of dopamine D2 receptor occupancy by lurasidone using positron emission tomography in healthy male subjects

    A positron emission tomography (PET) study of dopamine D2 receptor occupancy was conducted to support a rational dose selection for clinical efficacy studies with lurasidone, an atypical antipsychotic that was ap...

    Dean F. Wong, Hiroto Kuwabara, James Robert Brašić, Thomas Stock… in Psychopharmacology (2013)

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    Article

    Increased Cerebral Oxygen Metabolism and Ischemic Stress in Subjects with Metabolic Syndrome-Associated Risk Factors: Preliminary Observations

    Hypertension, diabetes, obesity, and dyslipidemia are risk factors that characterize metabolic syndrome (MetS), which increases the risk for stroke by 40%. In a preliminary study, our aim was to evaluate cereb...

    Ken Uchino, Ridwan Lin, Syed F. Zaidi, Hiroto Kuwabara… in Translational Stroke Research (2010)

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    Article

    White Matter Correlates of Cognitive Capacity Studied With Diffusion Tensor Imaging: Implications for Cognitive Reserve

    Cognitive reserve (CR) is a theoretical concept used to explain and study individual differences in cognitive symptom expression in neurological disease. In the absence of neurologic injury or demands on proce...

    Marc W. Haut, Maria T. Moran, Melissa A. Lancaster… in Brain Imaging and Behavior (2007)

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    Article

    Dose effects of triazolam on brain activity during episodic memory encoding: a PET study

    Although it is well established that acute benzodiazepine administration impairs episodic memory encoding, little is known about the neuroanatomical substrates of this effect.

    Miriam Z. Mintzer, Hiroto Kuwabara, Mohab Alexander, James R. Brasic… in Psychopharmacology (2006)