5 Result(s)
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Article
Open AccessA genome-wide gene-environment interaction study of breast cancer risk for women of European ancestry
Genome-wide studies of gene–environment interactions (G×E) may identify variants associated with disease risk in conjunction with lifestyle/environmental exposures. We conducted a genome-wide G×E analysis of ~...
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Article
Open AccessCYP27A1 expression is associated with risk of late lethal estrogen receptor-positive breast cancer in postmenopausal patients
27-Hydroxycholesterol (27HC) stimulates estrogen receptor-positive (ER+) breast cancer (BC) progression. Inhibiting the sterol 27-hydroxylase (CYP27A1) abrogates these growth-promoting effects of 27HC in mice....
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Article
Open AccessStellate cells and mesenchymal stem cells in benign mammary stroma are associated with risk factors for breast cancer – an observational study
It is not known whether stromal cells in benign breast tissue can mediate risk of breast cancer. We recently described aldehyde dehydrogenase 1 A1 (ALDH1) positive (+) cells in morphologically normal breast st...
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Article
Open AccessCYP1A2 – a novel genetic marker for early aromatase inhibitor response in the treatment of breast cancer patients
Endocrine resistance is a major obstacle to optimal treatment effect in breast cancer. Some genetic markers have been proposed to predict response to aromatase inhibitors (AIs) but the data is insufficient. Th...
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Article
Open AccessIL6 genotype, tumour ER-status, and treatment predicted disease-free survival in a prospective breast cancer cohort
In breast cancer, high levels of the inflammatory cytokine interleukin-6 (IL-6) have been associated with disease-free survival and treatment resistance. Increased serum levels of IL-6 have been correlated wit...
