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  1. Article

    Open Access

    Re-evaluation of HER2 status in 606 breast cancers—gene protein assay on tissue microarrays versus routine pathological assessment

    Human epidermal growth factor receptor 2 (HER2) status in breast cancer is routinely determined through immunohistochemistry (IHC) and/or in situ hybridisation (ISH) performed on whole tissue sections (WS). Th...

    Emma Sandén, Somayeh Khazaei, Helga Tryggvadottir, Signe Borgquist in Virchows Archiv (2020)

  2. Article

    Open Access

    Tumor-specific expression of HMG-CoA reductase in a population-based cohort of breast cancer patients

    The mevalonate pathway synthetizes cholesterol, steroid hormones, and non-steriod isoprenoids necessary for cell survival. 3-Hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) is the rate-limiting enzyme of...

    Emma Gustbée, Helga Tryggvadottir, Andrea Markkula in BMC Clinical Pathology (2015)

  3. Article

    Open Access

    Women with familial risk for breast cancer have an increased frequency of aldehyde dehydrogenase expressing cells in breast ductules

    Knowledge is limited regarding the association between stem cells in histologically benign breast tissue and risk factors for breast cancer, and hence we addressed this issue in the present study. Recently, we...

    Björn L Isfoss, Bo Holmqvist, Helena Jernström, Per Alm in BMC Clinical Pathology (2013)