20 Result(s)
within
Helena Jernström
Oncology
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Article
Open AccessPotential interplay between tumor size and vitamin D receptor (VDR) polymorphisms in breast cancer prognosis: a prospective cohort study
Vitamin D has some anticancer properties that may decrease breast cancer risk and improve prognosis. The aim was to investigate associations between four previously studied VDR SNPs (Taq1, Tru91, Bsm1, and Fok1) ...
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Open AccessA genome-wide gene-environment interaction study of breast cancer risk for women of European ancestry
Genome-wide studies of gene–environment interactions (G×E) may identify variants associated with disease risk in conjunction with lifestyle/environmental exposures. We conducted a genome-wide G×E analysis of ~...
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Open AccessCaveolin-1 genotypes as predictor for locoregional recurrence and contralateral disease in breast cancer
Caveolin-1 (CAV1) has been implicated in breast cancer oncogenesis and metastasis and may be a potential prognosticator, especially for non-distant events. CAV1 functions as a master regulator of membrane tran...
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Open AccessCYP27A1 expression is associated with risk of late lethal estrogen receptor-positive breast cancer in postmenopausal patients
27-Hydroxycholesterol (27HC) stimulates estrogen receptor-positive (ER+) breast cancer (BC) progression. Inhibiting the sterol 27-hydroxylase (CYP27A1) abrogates these growth-promoting effects of 27HC in mice....
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Open AccessThe impact of body size changes on recurrence risk depends on age and estrogen receptor status in primary breast cancer
To investigate the prognostic impact of body size changes during the first postoperative year in breast cancer.
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Article
Open AccessIncreasing preoperative body size in breast cancer patients between 2002 and 2016: implications for prognosis
Overweight and obesity are increasing worldwide, but the extent in breast cancer patients is unknown. The two aims were to study secular trends in preoperative body mass index (BMI), waist circumference, and b...
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Open AccessStellate cells and mesenchymal stem cells in benign mammary stroma are associated with risk factors for breast cancer – an observational study
It is not known whether stromal cells in benign breast tissue can mediate risk of breast cancer. We recently described aldehyde dehydrogenase 1 A1 (ALDH1) positive (+) cells in morphologically normal breast st...
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Open AccessCurrent smoking is associated with a larger waist circumference and a more androgenic profile in young healthy women from high-risk breast cancer families
The purpose was to elucidate the interplay between current smoking, anthropometric measurements, and endogenous hormone levels in women ≤ 40 years. Questionnaires on lifestyle and reproductive factors were com...
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Open AccessAndrogen receptor expression and breast cancer mortality in a population-based prospective cohort
The increase in clinical trials with androgen receptor (AR)-targeting drugs emphasizes the need of clarifying the role of AR expression in different breast cancer subtypes. AR confers good prognosis in estroge...
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Open AccessImpacts of smoking on endocrine treatment response in a prospective breast cancer cohort
The association between smoking and breast cancer prognosis remains unclear. The purpose of this study was to investigate whether preoperative smoking was associated with prognosis in different treatment groups.
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Article
Open AccessCYP1A2 – a novel genetic marker for early aromatase inhibitor response in the treatment of breast cancer patients
Endocrine resistance is a major obstacle to optimal treatment effect in breast cancer. Some genetic markers have been proposed to predict response to aromatase inhibitors (AIs) but the data is insufficient. Th...
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Article
History of oral contraceptive use in breast cancer patients: impact on prognosis and endocrine treatment response
The purpose was to study oral contraceptive (OC) use in relation to breast cancer events and endocrine treatment response in a prospective population-based cohort, because it is unclear whether history of OC u...
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Open AccessIL6 genotype, tumour ER-status, and treatment predicted disease-free survival in a prospective breast cancer cohort
In breast cancer, high levels of the inflammatory cytokine interleukin-6 (IL-6) have been associated with disease-free survival and treatment resistance. Increased serum levels of IL-6 have been correlated wit...
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Article
Age at first childbirth and oral contraceptive use are associated with risk of androgen receptor-negative breast cancer: the Malmö Diet and Cancer Cohort
Risk factors for breast cancer vary according to breast cancer subtype. This study analyzes the impact of potential risk factors in breast cancer by androgen receptor (AR) status.
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Article
Coffee prevents early events in tamoxifen-treated breast cancer patients and modulates hormone receptor status
Whether coffee modulates response to endocrine therapy in breast cancer patients is currently unknown. The CYP1A2 and CYP2C8 enzymes contribute to tamoxifen and caffeine metabolism. The purpose was to investig...
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Given breast cancer, is fat better than thin? Impact of the estrogen receptor beta gene polymorphisms
The role of estrogen receptor beta (ERβ) in breast cancer has been investigated since its identification in 1996. Studies based on protein expression have indicated that ERβ is a favorable prognostic marker. F...
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Article
Given breast cancer, does breast size matter? Data from a prospective breast cancer cohort
Body mass index (BMI), waist-to-hip ratio (WHR), and tumor characteristics affect disease-free survival. Larger breast size may increase breast cancer risk, but its influence on disease-free survival is unclea...
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Article
Breast cancer and spider telangiectasias at diagnosis and its relation to histopathology and prognosis: a population-based study
Angiogenesis is one of the hallmarks of breast cancer. The status of angiogenesis is important in therapy choice. Spider telangiectasias (telangiectasias) may reflect an increased ability to form vessels. Our ...
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Article
IGFBP1 and IGFBP3 polymorphisms predict circulating IGFBP-3 levels among women from high-risk breast cancer families
The insulin-like growth factor (IGF) pathway has been implicated as risk modifier in premenopausal breast cancer. In this study, associations between single nucleotide polymorphisms (SNPs) and diplotypes in the I...
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Article
A prospective study of different types of hormone replacement therapy use and the risk of subsequent breast cancer: the women's health in the Lund area (WHILA) study (Sweden)
Objectives: Reports suggest that combined estrogen plus progestin hormone replacement therapy (HRT) confers a higher breast cancer risk than estrogen alone. We aimed to establish whether breast cancer risk depen...
