2,748 Result(s)

Article

The combination of temozolomide and perifosine synergistically inhibit glioblastoma by impeding DNA repair and inducing apoptosis

Temozolomide (TMZ) is widely utilized as the primary chemotherapeutic intervention for glioblastoma. However, the clinical use of TMZ is limited by its various side effects and resistance to chemotherapy. The ...

Wenpeng Zhao, Liwei Zhou, Wentao Zhao, Huiying Yang, Zhenwei Lu… in Cell Death Discovery (2024)

Article

Dietary restriction promote sperm remodeling in aged roosters based on transcriptome analysis

The breeder rooster has played a pivotal role in poultry production by providing high-quality semen. Typically, fertility peaks between 30 and 40 weeks of age and then declines rapidly from 45 to 55 weeks of a...

Wenjie Liang, Yuehua He, Tingqi Zhu, Binbin Zhang, Shuangxing Liu… in BMC Genomics (2024)

Article

Short-chain fatty acids suppresses astrocyte activation by amplifying Trp-AhR-AQP4 signaling in experimental autoimmune encephalomyelitis mice

The function of astrocytes in response to gut microbiota-derived signals has an important role in the pathophysiological processes of central nervous system (CNS) diseases. However, the specific effects of mic...

**uli Lin, Yufeng Peng, Zhimei Guo, Wuhui He… in Cellular and Molecular Life Sciences (2024)

Article

RNA 2'-O-methylation promotes persistent R-loop formation and AID-mediated IgH class switch recombination

RNA–DNA hybrids or R-loops are associated with deleterious genomic instability and protective immunoglobulin class switch recombination (CSR). However, the underlying phenomenon regulating the two contrasting ...

Muzaffer Ahmad Kassab, Yibin Chen, **n Wang, Bo He, Eric J. Brown… in BMC Biology (2024)

Article

Integrative analysis of genomic and epigenomic regulation reveals miRNA mediated tumor heterogeneity and immune evasion in lower grade glioma

The expression dysregulation of microRNAs (miRNA) has been widely reported during cancer development, however, the underling mechanism remains largely unanswered. In the present work, we performed a systematic...

Zhen Yang, **aocen Liu, Hao Xu, Andrew E. Teschendorff… in Communications Biology (2024)

Article

Phase separation of RNF214 promotes the progression of hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is one of the most common malignant tumors, and the expression and function of an uncharacterized protein RNF214 in HCC are still unknown. Phase separation has recently been obse...

Zheng-Jie He, Ke He, Song-Wang Cai, Rui Zhang, Zhong-Bao Shao… in Cell Death & Disease (2024)

Article

Epigenetic regulation of DNA repair gene program by Hippo/YAP1-TET1 axis mediates sorafenib resistance in HCC

Hepatocellular carcinoma (HCC) is a malignancy that occurs worldwide and is generally associated with poor prognosis. The development of resistance to targeted therapies such as sorafenib is a major challenge ...

Chunli Mo, Weixin You, Yipeng Rao, Zhen** Lin… in Cellular and Molecular Life Sciences (2024)

Article

Functional and evolutionary comparative analysis of the DIR gene family in Nicotiana tabacum L. and Solanum tuberosum L.

The dirigent (DIR) genes encode proteins that act as crucial regulators of plant lignin biosynthesis. In Solanaceae species, members of the DIR gene family are intricately related to plant growth and development,...

Tong Li, Wenbin Luo, Chaofan Du, **aolu Lin, Guojian Lin, Rui Chen… in BMC Genomics (2024)

Article

Metabolomic and transcriptomic analyses of peach leaves and fruits in response to pruning

Pruning is an important cultivation management option that has important effects on peach yield and quality. However, the effects of pruning on the overall genetic and metabolic changes in peach leaves and fru...

**ao-Fei Liu, **u-Hong An, **n-Miao Li, He Zhang, Hong-Bo Cao… in BMC Genomics (2024)

Article

Author Correction: High-yield porphyrin production through metabolic engineering and biocatalysis

Haihong Chen, Yaohong Wang, Weishan Wang, Ting Cao, Lu Zhang… in Nature Biotechnology (2024)

Article

The circadian gene ARNTL2 promotes nasopharyngeal carcinoma invasiveness and metastasis through suppressing AMOTL2-LATS-YAP pathway

Metastasis is the major culprit of treatment failure in nasopharyngeal carcinoma (NPC). Aryl hydrocarbon receptor nuclear translocator like 2 (ARNTL2), a core circadian gene, plays a crucial role in the develo...

Wenqing Zou, Yiming Lei, Cong Ding, Hongjun **ao, Shunxin Wang… in Cell Death & Disease (2024)

Article

Erratum to: Cholesterol homeostasis regulated by ABCA1 is critical for retinal ganglion cell survival

Jialiang Yang, Yuhong Chen, Tongdan Zou, Bai Xue, Fang Yang… in Science China Life Sciences (2024)

Article

Influenza virus uses mGluR2 as an endocytic receptor to enter cells

Influenza virus infection is initiated by the attachment of the viral haemagglutinin (HA) protein to sialic acid receptors on the host cell surface. Most virus particles enter cells through clathrin-mediated e...

Zixin Ni, **liang Wang, **aofei Yu, Yifan Wang, **gfei Wang… in Nature Microbiology (2024)

Article

Gut fungi of black-necked cranes (Grus nigricollis) respond to dietary changes during wintering

Migratory birds exhibit heterogeneity in foraging strategies during wintering to cope with environmental and migratory pressures, and gut bacteria respond to changes in host diet. However, less is known about ...

Wenhao Li, Lijun Cheng, **n He, Guiwen He, Yutong Liu, Zhenglin Sang… in BMC Microbiology (2024)

Article

A single-cell sequence analysis of mouse subcutaneous white adipose tissue reveals dynamic changes during weaning

Adipose tissue development begins in the fetal period, and continues to expand after birth. Dysregulation of adipose tissue during weaning may predispose individuals to lifelong metabolic disorders. However, t...

Shuwen Qian, Chenyang Zhang, Yan Tang, Mengyuan Dai, Zhihui He… in Communications Biology (2024)

Article

Systematic single-cell analysis reveals dynamic control of transposable element activity orchestrating the endothelial-to-hematopoietic transition

The endothelial-to-hematopoietic transition (EHT) process during definitive hematopoiesis is highly conserved in vertebrates. Stage-specific expression of transposable elements (TEs) has been detected during z...

Cong Feng, Ruxiu Tie, Saige **n, Yuhao Chen, Sida Li, Yifan Chen… in BMC Biology (2024)

Article

Analysis of the aging-related biomarker in a nonhuman primate model using multilayer omics

Aging is a prominent risk factor for diverse diseases; therefore, an in-depth understanding of its physiological mechanisms is required. Nonhuman primates, which share the closest genetic relationship with hum...

Yunpeng Liu, Shuaiyao Lu, **g Yang, Yun Yang, Li Jiao, **gwen Hu… in BMC Genomics (2024)

Article

The MYB-like protein MylA contributes to conidiogenesis and conidial germination in Aspergillus nidulans

Myeloblastosis (MYB)-like proteins are a family of highly conserved transcription factors in animals, plants, and fungi and are involved in the regulation of mRNA expression of genes. In this study, we identif...

Ye-Eun Son, He-** Cho, Hee-Soo Park in Communications Biology (2024)

Article

AIM2 enhances Candida albicans infection through promoting macrophage apoptosis via AKT signaling

Candida albicans is among the most prevalent invasive fungal pathogens for immunocompromised individuals and novel therapeutic approaches that involve immune response modulation are imperative. Absent in melanoma...

Qian Jiang, Yayun Chen, Si** Zheng, Lina Sui… in Cellular and Molecular Life Sciences (2024)

Article

Identification of metastasis-related genes for predicting prostate cancer diagnosis, metastasis and immunotherapy drug candidates using machine learning approaches

Prostate cancer (PCa) is the second leading cause of tumor-related mortality in men. Metastasis from advanced tumors is the primary cause of death among patients. Identifying novel and effective biomarkers is ...

YaXuan Wang, Bo Ji, Lu Zhang, **feng Wang, Jia**n He, BeiChen Ding… in Biology Direct (2024)