12,460 Result(s)
within
He** Lin
Science, Humanities and Social Sciences, multidisciplinary
-
Article
Open AccessLarge-scale whole-exome sequencing analyses identified protein-coding variants associated with immune-mediated diseases in 350,770 adults
The genetic contribution of protein-coding variants to immune-mediated diseases (IMDs) remains underexplored. Through whole exome sequencing of 40 IMDs in 350,770 UK Biobank participants, we identified 162 uni...
-
Article
Open AccessGenomic and single-cell analyses reveal genetic signatures of swimming pattern and diapause strategy in jellyfish
Jellyfish exhibit innovative swimming patterns that contribute to exploring the origins of animal locomotion. However, the genetic and cellular basis of these patterns remains unclear. Herein, we generated chr...
-
Article
Open AccessUrinary complement factor D is increased in primary malignant hypertension: a single-center, cross-sectional study
Kidney injury is one of the detrimental consequences of primary malignant hypertension (pMHTN). There is a paucity of non-invasive biomarkers to enhance diagnosis and elucidate the underlying mechanisms. This ...
-
Article
Open AccessAdenine base editing-mediated exon skip** restores dystrophin in humanized Duchenne mouse model
Duchenne muscular dystrophy (DMD) affecting 1 in 3500–5000 live male newborns is the frequently fatal genetic disease resulted from various mutations in DMD gene encoding dystrophin protein. About 70% of DMD-caus...
-
Article
Open AccessIdentification of candidate single-nucleotide polymorphisms (SNPs) and genes associated with sugarcane leaf scald disease
Leaf scald, caused by Xanthomonas albilineans, is a severe disease affecting sugarcane worldwide. One of the most practical ways to control it is by develo** resistant sugarcane cultivars. It is essential to id...
-
Article
Open AccessPeripheral immunity is associated with cognitive impairment after acute minor ischemic stroke and transient ischemic attack
Immunoinflammation is associated with the development of post-stroke cognitive impairment (PSCI), however, peripheral immunity has not been fully explored. We aimed to investigate the association between PSCI ...
-
Article
Open AccessEnhanced electrocatalytic biomass oxidation at low voltage by Ni2+-O-Pd interfaces
Challenges in direct catalytic oxidation of biomass-derived aldehyde and alcohol into acid with high activity and selectivity hinder the widespread biomass application. Herein, we demonstrate that a Pd/Ni(OH)2 ca...
-
Article
Open AccessSilicon photocathode functionalized with osmium complex catalyst for selective catalytic conversion of CO2 to methane
Solar-driven CO2 reduction to yield high-value chemicals presents an appealing avenue for combating climate change, yet achieving selective production of specific products remains a significant challenge. We show...
-
Article
Open AccessCholine consumption reduces CVD risk via body composition modification
Despite extensive research on the relationship between choline and cardiovascular disease (CVD), conflicting findings have been reported. We aim to investigate the relationship between choline and CVD. Our ana...
-
Article
Open AccessAgCNER, the First Large-Scale Chinese Named Entity Recognition Dataset for Agricultural Diseases and Pests
Named entity recognition is a fundamental subtask for knowledge graph construction and question-answering in the agricultural diseases and pests field. Although several works have been done, the scarcity of th...
-
Article
Open AccessEffect of early endothelial function improvement on subclinical target organ damage in hypertensives
Endothelial dysfunction is acknowledged as a marker for subclinical target organ damage (STOD) in hypertension, though its therapeutic potential has not yet been clarified. This study assessed whether early en...
-
Article
Open AccessDevelopment of implantable electrode based on bioresorbable Mg alloy for tissue welding application
An implantable electrode based on bioresorbable Mg-Nd-Zn-Zr alloy was developed for next-generation radiofrequency (RF) tissue welding application, aiming to reduce thermal damage and enhance anastomotic stren...
-
Article
Open AccessInhibition of DUSP18 impairs cholesterol biosynthesis and promotes anti-tumor immunity in colorectal cancer
Tumor cells reprogram their metabolism to produce specialized metabolites that both fuel their own growth and license tumor immune evasion. However, the relationships between these functions remain poorly unde...
-
Article
Open AccessModified ventriculoperitoneal shunt applied to temporary external ventricular drainage
External ventricular drainage (EVD) is a common procedure in neurosurgical practice. Presently, the three methods used most often include direct EVD (dEVD), long-tunneled external ventricular drains (LTEVDs), ...
-
Article
Open AccessA liver immune rheostat regulates CD8 T cell immunity in chronic HBV infection
Chronic hepatitis B virus (HBV) infection affects 300 million patients worldwide1,2, in whom virus-specific CD8 T cells by still ill-defined mechanisms lose their function and cannot eliminate HBV-infected hepato...
-
Article
Open AccessHistamine H1 receptors in dentate gyrus-projecting cholinergic neurons of the medial septum suppress contextual fear retrieval in mice
Fear memory is essential for survival and adaptation, yet excessive fear memories can lead to emotional disabilities and mental disorders. Despite previous researches have indicated that histamine H1 receptor (H1
-
Article
Open AccessAssociation between composite dietary antioxidant index and hyperlipidemia: a cross-sectional study from NHANES (2005–2020)
The association between the composite dietary antioxidant index (CDAI) and hyperlipidemia remains unclear. Therefore, this study aimed to investigate the relationship between CDAI and hyperlipidemia. The data ...
-
Article
Interferon subverts an AHR–JUN axis to promote CXCL13+ T cells in lupus
Systemic lupus erythematosus (SLE) is prototypical autoimmune disease driven by pathological T cell–B cell interactions1,2. Expansion of T follicular helper (TFH) and T peripheral helper (TPH) cells, two T cell p...
-
Article
Open AccessAutomatic wild bird repellent system that is based on deep-learning-based wild bird detection and integrated with a laser rotation mechanism
Wild bird repulsion is critical in agriculture because it helps avoid agricultural food losses and mitigates the risk of avian influenza. Wild birds transmit avian influenza in poultry farms and thus cause lar...
-
Article
Open AccessWavelength-tunable high-fidelity entangled photon sources enabled by dual Stark effects
The construction of a large-scale quantum internet requires quantum repeaters containing multiple entangled photon sources with identical wavelengths. Semiconductor quantum dots can generate entangled photon p...
