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  1. No Access

    Chapter

    Effects of the Beta-Adrenoceptor Blocker Carvedilol in Children with Myocardial Failure

    We performed a prospective, open study to evaluate the clinical effect of Carvedilol among pediatric patients with myocardial failure (CHF) failing to reply sufficiently to standard therapy. In addition, we as...

    Hasso Scholz, Stephanie Läer MD, Frederike Behn… in Cardiac Remodeling and Failure (2003)

  2. No Access

    Article

    Pharmacological aspects of calcium channel blockers

    Calcium channel blockers (CCBs) inhibit voltagedependent L-type calcium channels. This leads to vascular smooth muscle relaxation and negative inotropic and chronotropic effects in the heart. The latter are co...

    Hasso Scholz in Cardiovascular Drugs and Therapy (1997)

  3. No Access

    Chapter and Conference Paper

    Receptor-Mediated Regulation of Cardiac Contractility: lnotropic Effects of Alpha-Adrenoceptor Stimulation with Phenylephrine and Noradrenaline in Failing Human Hearts

    In the failing human heart, the beta-adrenergic positive inotropic effect (PIE) is attenuated. It is conceivable that in compensation alpha-adrenoceptor-mediated inotropism may gain importance under these cond...

    Hasso Scholz, Thomas Eschenhagen… in Molecular and Cellular Mechanisms of Cardi… (1996)

  4. No Access

    Article

    Introduction: Mechanisms of positive inotropic effects

    This review deals with the principal mechanisms which are known to play a role in positive inotropism: 1) The myoplasmic Ca2+ concentration may be increased by increases in cyclic AMP. Beside receptor-mediated st...

    Hasso Scholz in Basic Research in Cardiology (1989)