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Article
Immunohistochemical analysis of transporters related to clearance of amyloid-β peptides through blood–cerebrospinal fluid barrier in human brain
A large number of previous reports have focused on the transport of amyloid-β peptides through cerebral endothelial cells via the blood–brain barrier, while fewer reports have mentioned the transport through t...
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Article
The expression of LDL receptor in vessels with blood–brain barrier impairment in a stroke-prone hypertensive model
We previously reported that the blood–brain barrier (BBB) function was deteriorated in vessels located in the hippocampus in stroke-prone spontaneously hypertensive rats (SHRSP). In order to assess whether sub...
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Article
Two pathways of apoptosis are simultaneously induced in the embryonal brains of neural cell-specific HIF-1α-deficient mice
The aim of this study was to clarify the mechanism of apoptosis seen in the cortex of neural cell-specific hypoxia inducible factor-1α (HIF-1α)-deficient embryos. A previous study showed that the neural cells ...
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Article
Blood-brain barrier disruption in the hypothalamus of young adult spontaneously hypertensive rats
Vascular permeability and endothelial glycocalyx were examined in young adult spontaneously hypertensive rats (SHR), stroke-prone SHR (SHRSP), and Wistar Kyoto rats (WKY) as a control, in order to determine ea...