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within Harmen J. G. van de Werken Remove this filter Human Genetics Remove this filter

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  1. Article

    Open Access

    Functional RECAP (REpair CAPacity) assay identifies homologous recombination deficiency undetected by DNA-based BRCAness tests

    Germline BRCA1/2 mutation status is predictive for response to Poly-[ADP-Ribose]-Polymerase (PARP) inhibitors in breast cancer (BC) patients. However, non-germline BRCA1/2 mutated and homologous recombination rep...

    Titia G. Meijer, Luan Nguyen, Arne Van Hoeck, Anieta M. Sieuwerts… in Oncogene (2022)

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  2. No Access

    Article

    The genomic landscape of metastatic breast cancer highlights changes in mutation and signature frequencies

    The whole-genome sequencing of prospectively collected tissue biopsies from 442 patients with metastatic breast cancer reveals that, compared to primary breast cancer, tumor mutational burden doubles, the rela...

    Lindsay Angus, Marcel Smid, Saskia M. Wilting, Job van Riet… in Nature Genetics (2019)

  3. Article

    Open Access

    The detailed 3D multi-loop aggregate/rosette chromatin architecture and functional dynamic organization of the human and mouse genomes

    The dynamic three-dimensional chromatin architecture of genomes and its co-evolutionary connection to its function—the storage, expression, and replication of genetic information—is still one of the central i...

    Tobias A. Knoch, Malte Wachsmuth, Nick Kepper, Michael Lesnussa… in Epigenetics & Chromatin (2016)

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