3 Result(s)
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Harmen J. G. van de Werken
Computational Biology/Bioinformatics
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Article
Open AccessFASTAFS: file system virtualisation of random access compressed FASTA files
The FASTA file format, used to store polymeric sequence data, has become a bioinformatics file standard used for decades. The relatively large files require additional files, beyond the scope of the original f...
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Article
Open AccessGene length corrected trimmed mean of M-values (GeTMM) processing of RNA-seq data performs similarly in intersample analyses while improving intrasample comparisons
Current normalization methods for RNA-sequencing data allow either for intersample comparison to identify differentially expressed (DE) genes or for intrasample comparison for the discovery and validation of g...
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Article
Investigation of the spatial structure and interactions of the genome at sub-kilobase-pair resolution using T2C
This protocol describes targeted chromatin capture (T2C), a high-resolution method to interrogate 3D chromatin organization and genomic interactions at sub-kilobase-pair resolution that requires minimal cell n...
