315 Result(s)
-
Article
Open AccessMAST4 regulates stem cell maintenance with DLX3 for epithelial development and amelogenesis
The asymmetric division of stem cells permits the maintenance of the cell population and differentiation for harmonious progress. Develo** mouse incisors allows inspection of the role of the stem cell niche ...
-
Article
Cell membrane camouflaged nanoparticle strategy and its application in brain disease: a review
Drug delivery to the brain is difficult, owing of the presence of a unique structure called the blood–brain barrier (BBB). Thus, strategies that facilitate drug delivery to the brain lesion sites via BBB penet...
-
Article
Genotoxicity and safety pharmacology of the rVSVInd(GML)-mspSGtc vaccine against SARS-CoV-2 in Sprague–Dawley rats and Beagle dogs
The emergence of coronavirus disease (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) led to a pandemic, prompting rapid vaccine development. Although vaccines are effective, t...
-
Article
Multi-parametric atlas of the pre-metastatic liver for prediction of metastatic outcome in early-stage pancreatic cancer
Metastasis occurs frequently after resection of pancreatic cancer (PaC). In this study, we hypothesized that multi-parametric analysis of pre-metastatic liver biopsies would classify patients according to thei...
-
Article
Open AccessAntitumor activity of afatinib in EGFR T790M-negative human oral cancer therapeutically targets mTOR/Mcl-1 signaling axis
This study investigates the role and effectiveness of the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor (TKI) in oral cancer, focusing on the clinical relevance of EGFR and myeloid cell leu...
-
Article
Open AccessEditorial expression of concern: Protective effect of Curcuma longa L. extract on CCl4-induced acute hepatic stress
-
Article
Open AccessBiomaterials-enabled electrical stimulation for tissue healing and regeneration
The electrical microenvironment is considered a pivotal determinant in various pathophysiological processes, including tissue homeostasis and wound healing. Consequently, extensive research endeavors have been...
-
Article
Open AccessAntileukemic potential of methylated indolequinone MAC681 through immunogenic necroptosis and PARP1 degradation
Despite advancements in chronic myeloid leukemia (CML) therapy with tyrosine kinase inhibitors (TKIs), resistance and intolerance remain significant challenges. Leukemia stem cells (LSCs) and TKI-resistant cel...
-
Article
A review on the nanotechnology-based approaches for managing sexually transmitted infections
Sexually transmitted infections (STIs) are a major public health concern, accounting for millions of new infections each year and a high mortality rate. Acute diseases and infertility are also associated with ...
-
Article
Open AccessRNA expression of 6 genes from metastatic mucosal gastric cancer serves as the global prognostic marker for gastric cancer with functional validation
Molecular analysis of advanced tumors can increase tumor heterogeneity and selection bias. We developed a robust prognostic signature for gastric cancer by comparing RNA expression between very rare early gast...
-
Article
Open AccessTLR7-dependent eosinophil degranulation links psoriatic skin inflammation to small intestinal inflammatory changes in mice
Recent evidence of gut microbiota dysbiosis in the context of psoriasis and the increased cooccurrence of inflammatory bowel disease and psoriasis suggest a close relationship between skin and gut immune respo...
-
Article
Integrative multi-omics profiling in human decedents receiving pig heart xenografts
In a previous study, heart xenografts from 10-gene-edited pigs transplanted into two human decedents did not show evidence of acute-onset cellular- or antibody-mediated rejection. Here, to better understand th...
-
Article
Layered silicate nanoparticles as a non-injectable drug delivery system for biomacromolecules
Safe, efficient, and patient-friendly drug delivery systems are critical for enhancing therapeutic efficacy and the clinical application of drugs. Hence, various organic, inorganic, and hybrid materials have b...
-
Article
Open AccessOvercoming BRAF and CDK4/6 inhibitor resistance by inhibiting MAP3K3-dependent protection against YAP lysosomal degradation
Transcriptional programs governed by YAP play key roles in conferring resistance to various molecular-targeted anticancer agents. Strategies aimed at inhibiting YAP activity have garnered substantial interest ...
-
Article
Open AccessRecent advances in extracellular vesicles for therapeutic cargo delivery
Exosomes, which are nanosized vesicles secreted by cells, are attracting increasing interest in the field of biomedical research due to their unique properties, including biocompatibility, cargo loading capaci...
-
Article
The impact of physical disability on the risk of gastric cancer incidence in elderly patients with diabetes: a focus on regional disparity
Elderly patients with type 2 diabetes mellitus (T2DM) may have a higher risk of physical disability. This study investigated the incidence of gastric cancer according to physical disability status in elderly p...
-
Article
Open AccessBCG-booster vaccination with HSP90-ESAT-6-HspX-RipA multivalent subunit vaccine confers durable protection against hypervirulent Mtb in mice
The quest for effective and enhanced multiantigenic tuberculosis (TB) subunit vaccine necessitates the induction of a protective pathogen-specific immune response while circumventing detrimental inflammation w...
-
Article
Open AccessSynergistic toxicity with copper contributes to NAT2-associated isoniazid toxicity
Anti-tuberculosis (AT) medications, including isoniazid (INH), can cause drug-induced liver injury (DILI), but the underlying mechanism remains unclear. In this study, we aimed to identify genetic factors that...
-
Article
Open AccessDysregulated CREB3 cleavage at the nuclear membrane induces karyoptosis-mediated cell death
Cancer cells often exhibit resistance to apoptotic cell death, but they may be vulnerable to other types of cell death. Elucidating additional mechanisms that govern cancer cell death is crucial for develo**...
-
Article
Open AccessAcetyl-CoA synthetase 2 contributes to a better prognosis for liver cancer by switching acetate-glucose metabolism
Acetyl-CoA synthetase 2 (ACSS2)-dependent acetate usage has generally been associated with tumorigenesis and increased malignancy in cancers under nutrient-depleted conditions. However, the nutrient usage and ...
