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Article
Open AccessA midbrain GABAergic circuit constrains wakefulness in a mouse model of stress
Enhancement of wakefulness is a prerequisite for adaptive behaviors to cope with acute stress, but hyperarousal is associated with impaired behavioral performance. Although the neural circuitries promoting wak...
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Article
Open AccessBNST GABAergic neurons modulate wakefulness over sleep and anesthesia
The neural circuits underlying sleep-wakefulness and general anesthesia have not been fully investigated. The GABAergic neurons in the bed nucleus of the stria terminalis (BNST) play a critical role in stress ...
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Article
Open AccessPrevalence and risk factors for astigmatism in 7 to 19-year-old students in **njiang, China: a cross-sectional study
To investigate the prevalence and risk factors for astigmatism in 7-19-year-old students in **njiang, China.
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Article
Open AccessImpact of hyperoxia on the gut during critical illnesses
Molecular oxygen is typically delivered to patients via oxygen inhalation or extracorporeal membrane oxygenation (ECMO), potentially resulting in systemic hyperoxia from liberal oxygen inhalation or localized ...
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Article
Open AccessHypothalamic supramammillary neurons that project to the medial septum modulate wakefulness in mice
The hypothalamic supramammillary nucleus (SuM) plays a crucial role in controlling wakefulness, but the downstream target regions participating in this control process remain unknown. Here, using circuit-speci...
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Article
Open AccessConstruction and validation of a metabolic-related genes prognostic model for oral squamous cell carcinoma based on bioinformatics
Oral squamous cell carcinoma (OSCC) accounts for a frequently-occurring head and neck cancer, which is characterized by high rates of morbidity and mortality. Metabolism-related genes (MRGs) show close associa...
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Article
Open AccessLeptonic scalars and collider signatures in a UV-complete model
We study the non-standard interactions of neutrinos with light leptonic scalars (ϕ) in a global (B − L)-conserved ultraviolet (UV)-complete model. The model utilizes Type-II seesaw motivated neutrino interactions...
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Article
Open AccessGenome shuffling enhances stress tolerance of Zymomonas mobilis to two inhibitors
Furfural and acetic acid are the two major inhibitors generated during lignocellulose pretreatment and hydrolysis, would severely inhibit the cell growth, metabolism, and ethanol fermentation efficiency of Zymomo...
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Article
Open AccessReplacing water and nutrients for ethanol production by ARTP derived biogas slurry tolerant Zymomonas mobilis strain
Reducing fresh water consumption and nutrient addition will be an effective way to reduce the whole cost of bioethanol production. On the other hand, treatment of biogas slurry derived from anaerobic digestion...
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Article
Open AccessEngineered Zymomonas mobilis tolerant to acetic acid and low pH via multiplex atmospheric and room temperature plasma mutagenesis
Cellulosic biofuels are sustainable compared to fossil fuels. However, inhibitors, such as acetic acid generated during lignocellulose pretreatment and hydrolysis, would significantly inhibit microbial ferment...
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Article
Open AccessReplacing process water and nitrogen sources with biogas slurry during cellulosic ethanol production
Environmental issues, such as the fossil energy crisis, have resulted in increased public attention to use bioethanol as an alternative renewable energy. For ethanol production, water and nutrient consumption ...
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Article
Open AccessTargeted Patching and Dendritic Ca2+ Imaging in Nonhuman Primate Brain in vivo
Nonhuman primates provide an important model not only for understanding human brain but also for translational research in neurological and psychiatric disorders. However, many high-resolution techniques for r...
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Article
Open AccessEngineered Zymomonas mobilis for salt tolerance using EZ-Tn5-based transposon insertion mutagenesis system
The cell growth and ethanol yield of Zymomonas mobilis may be detrimentally affected by salt stress frequently present in some biomass-based fermentation systems, leading to a decrease in the rate of sugar conver...
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Open AccessUsing global transcription machinery engineering (gTME) to improve ethanol tolerance of Zymomonas mobilis
With the increasing global crude oil crisis and resulting environmental concerns, the production of biofuels from renewable resources has become increasingly important. One of the major challenges faced during...
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Article
Open AccessZymomonas mobilis: a novel platform for future biorefineries
Biosynthesis of liquid fuels and biomass-based building block chemicals from microorganisms have been regarded as a competitive alternative route to traditional. Zymomonas mobilis possesses a number of desirable ...
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Article
Open AccessComparative expression profiles of microRNA in left and right atrial appendages from patients with rheumatic mitral valve disease exhibiting sinus rhythm or atrial fibrillation
The atrial fibrillation (AF) associated microRNAs (miRNAs) were found in the right atrium (RA) and left atrium (LA) from patients with rheumatic mitral valve disease (RMVD). However, most studies only focus on...
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Article
Open AccessAtrial fibrillation alters the microRNA expression profiles of the left atria of patients with mitral stenosis
Structural changes of the left and right atria associated with atrial fibrillation (AF) in mitral stenosis (MS) patients are well known, and alterations in microRNA (miRNA) expression profiles of the right atr...
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Article
Open AccessThe altered expression profile of microRNAs in cardiopulmonary bypass canine models and the effects of mir-499 on myocardial ischemic reperfusion injury
MicroRNAs were enrolled in various cardiovascular disease especially ischemic heart diseases, but the microRNA changes during myocardial ischemia reperfusion injury underwent cardiopulmonary bypass are still u...
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Article
Efficient generation of hepatocyte-like cells from human induced pluripotent stem cells
Human induced pluripotent stem (iPS) cells are similar to embryonic stem (ES) cells, and can proliferate intensively and differentiate into a variety of cell types. However, the hepatic differentiation of huma...
