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  1. No Access

    Article

    Phosphatidylinositol-3-OH kinase/AKT and survivin pathways as critical targets for geranylgeranyltransferase I inhibitor-induced apoptosis

    Geranylgeranyltransferase I inhibitors (GGTIs) represent a new class of anticancer drugs. However, the mechanism by which GGTIs inhibit tumor cell growth is still unclear. Here, we demonstrate that GGTI-298 an...

    Han C Dan, Kun Jiang, Domenico Coppola, Andrew Hamilton, Santo V Nicosia… in Oncogene (2004)

  2. Article

    Open Access

    Simvastatin induces cell cycle arrest and inhibits proliferation of bladder cancer cells via PPARγ signalling pathway

    Simvastatin is currently one of the most common drugs for old patients with hyperlipidemia, hypercholesterolemia and atherosclerotic diseases by reducing cholesterol level and anti-lipid properties. Importantl...

    Gang Wang, Rui Cao, Yongzhi Wang, Guofeng Qian, Han C. Dan, Wei Jiang… in Scientific Reports (2016)

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