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    Production of recombinant granulocyte colony-stimulating factor by knocking into the active immunoglobulin heavy chain gene locus in the hybridoma cell line

    The hybridoma cell line KM50 originally produces a monoclonal antibody at a concentration of ∼40 mg ml-1 in ascites. To investigate the possibility to apply this expression system to the production of useful prot...

    Yoshihisa Kuwana, Kikuko Funayama, Hiromasa Miyaji, Mamoru Hasegawa… in Cytotechnology (2001)