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  1. Article

    Open Access

    Single-cell transcriptome analysis of tumor and stromal compartments of pancreatic ductal adenocarcinoma primary tumors and metastatic lesions

    Solid tumors such as pancreatic ductal adenocarcinoma (PDAC) comprise not just tumor cells but also a microenvironment with which the tumor cells constantly interact. Detailed characterization of the cellular ...

    Wei Lin, Pawan Noel, Erkut H. Borazanci, Jeeyun Lee, Albert Amini… in Genome Medicine (2020)

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    A DNA Polymerase Stop Assay for Characterization of G-Quadruplex Formation and Identification of G-Quadruplex-Interactive Compounds

    Guanine-rich DNA sequences are able to spontaneously fold into G-quadruplex structures in the presence of certain metal cations. In the human genome, the majority of DNA G-quadruplexes form at the telomeres an...

    Guanhui Wu, Haiyong Han in G-Quadruplex Nucleic Acids (2019)

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    RNA Interference to Knock Down Gene Expression

    RNA interference (RNAi) is a biological process by which double-stranded RNA (dsRNA) induces sequence-specific gene silencing by targeting mRNA for degradation. As a tool for knocking down the expression of in...

    Haiyong Han in Disease Gene Identification (2018)

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    Article

    Genetic variants at 4q21, 4q23 and 12q24 are associated with esophageal squamous cell carcinoma risk in a Chinese population

    A recently published genome-wide association study (GWAS) in European populations identified several loci at 4q21, 4q23 and 12q24 that were associated with risk of upper aerodigestive tract (UADT) cancers, inc...

    Yong Gao, Yisha He, **g Xu, Lin Xu, Jiangbo Du, Chen Zhu, Haiyong Gu… in Human Genetics (2013)

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    Article

    Association of a Tandem Repeat Polymorphism in NFATc1 with Increased Risk of Perimembranous Ventricular Septal Defect in a Chinese Population

    The nuclear factor of activated T lymphocytes (NFATc1) plays a critical role during valvular and septal development. Genetic variants may influence the biological function of the protein and thus play a role i...

    Haiyong Gu, Jie Gong, Wanshan Qiu, HaiLong Cao, **g Xu… in Biochemical Genetics (2011)