15 Result(s)

Article

Integrated proteogenomic characterization of medullary thyroid carcinoma

Medullary thyroid carcinoma (MTC) is a rare neuroendocrine malignancy derived from parafollicular cells (C cells) of the thyroid. Here we presented a comprehensive multi-omics landscape of 102 MTCs through who...

**ao Shi, Yaoting Sun, Cenkai Shen, Yan Zhang, Rongliang Shi, Fan Zhang… in Cell Discovery (2022)

Article

Author Correction: Artificial intelligence defines protein-based classification of thyroid nodules

Yaoting Sun, Sathiyamoorthy Selvarajan, Zelin Zang, Wei Liu, Yi Zhu… in Cell Discovery (2022)

Article

Artificial intelligence defines protein-based classification of thyroid nodules

Determination of malignancy in thyroid nodules remains a major diagnostic challenge. Here we report the feasibility and clinical utility of develo** an AI-defined protein-based biomarker panel for diagnostic...

Yaoting Sun, Sathiyamoorthy Selvarajan, Zelin Zang, Wei Liu, Yi Zhu… in Cell Discovery (2022)

Article

SGSM2 inhibits thyroid cancer progression by activating RAP1 and enhancing competitive RAS inhibition

Thyroid cancer (TC) is one of the most common malignancies involving the head and neck, and its incidences are increasing every year. Small G protein signaling modulators 2 (SGSM2) belongs to a newly identifie...

** Su, Dong Chen, Lizhang Zhu, Hao Jia, Jiaxuan Cai, Peng Li… in Cell Death & Disease (2022)

Article

LncRNA HOXA-AS2 promotes glioblastoma carcinogenesis by targeting miR-885-5p/RBBP4 axis

LncRNA HOXA-AS2 has been found in the literature to deteriorate glioblastoma. However, its regulatory mechanism is yet to be fully investigated. Our study focused chiefly on the interaction and role of the HOX...

Jixin Shou, Haidong Gao, Sen Cheng, Bingbing Wang, Haibo Guan in Cancer Cell International (2021)

Article

Negligible transcriptome and metabolome alterations in RNAi insecticidal maize against Monolepta hieroglyphica

RNAi-based genetically modified maize resistant to Monolepta hieroglyphica (Motschulsky) was demonstrated with negligible transcriptome and metabolome alterations compared to its unmodified equ...

**aolei Zhang, Ruiying Zhang, Liang Li, Yang Yang, Yijia Ding… in Plant Cell Reports (2020)

Article

CYP2S1 is a synthetic lethal target in BRAF^V600E-driven thyroid cancers

BRAF^V600E is the most common genetic alteration and has become a major therapeutic target in thyroid cancers; however, intrinsic feedback mechanism limited clinical use of BRAF^V600E specific inhibitors. Synthetic...

Yiqi Li, ** Su, Chao Feng, Siyu Liu… in Signal Transduction and Targeted Therapy (2020)

Article

Genome-wide characterization of the abscisic acid-, stress- and ripening-induced (ASR) gene family in wheat (Triticum aestivum L.)

Abscisic acid-, stress-, and ripening-induced (ASR) genes are a class of plant specific transcription factors (TFs), which play important roles in plant development, growth and abiotic stress responses. The wheat...

Huawei Li, Haiying Guan, Qicui Zhuo, Zongshuai Wang, Shengdong Li… in Biological Research (2020)

Article

Architecture of Saccharomyces cerevisiae SAGA complex

Gaochao Liu, **angdong Zheng, Haipeng Guan, Yong Cao, Hongyuan Qu… in Cell Discovery (2019)

Article

Gas41 links histone acetylation to H2A.Z deposition and maintenance of embryonic stem cell identity

The histone variant H2A.Z is essential for maintaining embryonic stem cell (ESC) identity in part by kee** developmental genes in a poised bivalent state. However, how H2A.Z is deposited into the bivalent do...

Chih-Chao Hsu, Dan Zhao, Jiejun Shi, Danni Peng, Haipeng Guan… in Cell Discovery (2018)

Article

YEATS2 is a selective histone crotonylation reader

Dan Zhao, Haipeng Guan, Shuai Zhao, Wenyi Mi, Hong Wen, Yuanyuan Li… in Cell Research (2016)

Article

The BAH domain of BAHD1 is a histone H3K27me3 reader

Dan Zhao, **aojie Zhang, Haipeng Guan, **aozhe **ong, **aomeng Shi… in Protein & Cell (2016)