19 Result(s)

Article

Oxidative degradation of dihydrofolate reductase increases CD38-mediated ferroptosis susceptibility

High expression of CD38 in tissues is a characteristic of aging, resulting in a decline in nicotinamide adenine dinucleotide (NAD) and increasing cellular reactive oxygen species (ROS). However, whether CD38 i...

Yingying Ma, Meiqi Yi, Weixuan Wang, **aohui Liu, Qingtao Wang… in Cell Death & Disease (2022)

Article

Exosomal miR-328 originated from pulmonary adenocarcinoma cells enhances osteoclastogenesis via downregulating Nrp-2 expression

Osseous metastases of pulmonary carcinoma and the detailed mechanisms remain unclear, and the effects of exosomes (Exos) originated from pulmonary adenocarcinoma cells in this process have received a lot of at...

Chengcheng Zhang, **gru Qin, Lu Yang, Zhiyao Zhu, Jia Yang, Wan Su… in Cell Death Discovery (2022)

Article

Targeting lactate dehydrogenase B-dependent mitochondrial metabolism affects tumor initiating cells and inhibits tumorigenesis of non-small cell lung cancer by inducing mtDNA damage

Once considered a waste product of anaerobic cellular metabolism, lactate has been identified as a critical regulator of tumorigenesis, maintenance, and progression. The putative primary function of lactate de...

Haibin Deng, Yanyun Gao, Verdiana Trappetti… in Cellular and Molecular Life Sciences (2022)

Article

Complex roles of nicotinamide N-methyltransferase in cancer progression

Nicotinamide N-methyltransferase (NNMT) is an intracellular methyltransferase, catalyzing the N-methylation of nicotinamide (NAM) to form 1-methylnicotinamide (1-MNAM), in which S-adenosyl-l-methionine (SAM) is t...

Weixuan Wang, Changmei Yang, Tianxiang Wang, Haiteng Deng in Cell Death & Disease (2022)

Article

Loss of Spike N370 glycosylation as an important evolutionary event for the enhanced infectivity of SARS-CoV-2

Shuyuan Zhang, Qingtai Liang, **nheng He, Chongchong Zhao, Wenlin Ren… in Cell Research (2022)

Article

N6-methyladenosine demethylase FTO promotes growth and metastasis of gastric cancer via m⁶A modification of caveolin-1 and metabolic regulation of mitochondrial dynamics

Gastric cancer (GC) is the fifth most common tumor and the third most deadly cancer worldwide. N6-methyladenosine (m⁶A) modification has been reported to play a regulatory role in human cancers. However, the exac...

You Zhou, Qi Wang, Haifeng Deng, Bin Xu, Yi Zhou, Jian Liu… in Cell Death & Disease (2022)

Article

Induced TRIM21 ISGylation by IFN-β enhances p62 ubiquitination to prevent its autophagosome targeting

The tripartite motif-containing protein 21 (TRIM21) plays important roles in autophagy and innate immunity. Here, we found that HECT and RLD domain containing E3 ubiquitin protein ligase 5 (HERC5), as an inter...

Jie **, **anbin Meng, Yi Huo, Haiteng Deng in Cell Death & Disease (2021)

Article

Cryo-EM structures of Lassa and Machupo virus polymerases complexed with cognate regulatory Z proteins identify targets for antivirals

Zoonotic arenaviruses can lead to life-threating diseases in humans. These viruses encode a large (L) polymerase that transcribes and replicates the viral genome. At the late stage of replication, the multifun...

**n Xu, Ruchao Peng, Qi Peng, Min Wang, Ying Xu, Sheng Liu… in Nature Microbiology (2021)

Article

The structural basis of function and regulation of neuronal cotransporters NKCC1 and KCC2

NKCC and KCC transporters mediate coupled transport of Na⁺+K⁺+Cl⁻ and K⁺+Cl⁻ across the plasma membrane, thus regulating cell Cl⁻ concentration and cell volume and playing critical roles in transepithelial salt a...

Sensen Zhang, Jun Zhou, Yuebin Zhang, Tianya Liu, Perrine Friedel… in Communications Biology (2021)

Article

COPII mitigates ER stress by promoting formation of ER whorls

Cells mitigate ER stress through the unfolded protein response (UPR). Here, we report formation of ER whorls as an effector mechanism of the ER stress response. We found that strong ER stress induces formation...

Fang Xu, Wanqing Du, Qin Zou, Yuting Wang, **n Zhang, Xudong **ng, Ying Li… in Cell Research (2021)

Article

POTEE drives colorectal cancer development via regulating SPHK1/p65 signaling

Aberrant gene expression plays critical roles in the development of colorectal cancer (CRC). Here we show that POTEE, which was identified as a member E of POTE ankyrin domain family, was significantly upregul...

Zhiyong Shen, **aochuang Feng, Yuan Fang, Yongsheng Li, Zhenkang Li… in Cell Death & Disease (2019)

Article

Simple β-lactones are potent irreversible antagonists for strigolactone receptors

Haibo **ang, Ruifeng Yao, Tianfei Quan, Fei Wang, Li Chen, … in Cell Research (2017)

Article

ShHTL7 is a non-canonical receptor for strigolactones in root parasitic weeds

Ruifeng Yao, Fei Wang, Zhenhua Ming, **aoxi Du, Li Chen, Yupei Wang… in Cell Research (2017)

Article

Fasting-induced hormonal regulation of lysosomal function

Lysosomes are centers for nutrient sensing and recycling that allow mammals to adapt to starvation. Regulation of lysosome dynamics by internal nutrient signaling is well described, but the mechanisms by which...

Liqun Chen, Ke Wang, Aijun Long, Liangjie Jia, Yuanyuan Zhang… in Cell Research (2017)

Article

A proposed role for glutamine in cancer cell growth through acid resistance

Weijiao Huang, Wooyoung Choi, Yuling Chen, Qi Zhang, Haiteng Deng, Wei He… in Cell Research (2013)

Article

L-glutamine provides acid resistance for Escherichia coli through enzymatic release of ammonia

Bacteria, exemplified by enteropathogenic Escherichia coli (E. coli), rely on elaborate acid resistance systems to survive acidic environment (such as the stomach). Comprehensive understanding of bacterial acid r...

Peilong Lu, Dan Ma, Yuling Chen, Yingying Guo, Guo-Qiang Chen… in Cell Research (2013)

Article

Design study for the cascaded HGHG experiment based on the SDUV-FEL

Cascading stages of high-gain harmonic generation (HGHG) free electron laser (FEL) is a promising way to produce fully coherent X-ray radiation. As a test facility for modern FEL R&D, the Shanghai deep ultravi...

Chao Feng, Meng Zhang, GuoQiang Lin, Qiang Gu, Hai**ao Deng… in Chinese Science Bulletin (2012)

Article

p38α MAP kinase phosphorylates RCAN1 and regulates its interaction with calcineurin

RCAN1, also known as DSCR1, is an endogenous regulator of calcineurin, a serine/threonine protein phosphatase that plays a critical role in many physiological processes. In this report, we demonstrate that p38...

Lei Ma, Hai** Tang, Yan Ren, HaiTeng Deng, JiaWei Wu… in Science China Life Sciences (2012)

Article

Crystal structure and biochemical analyses reveal Beclin 1 as a novel membrane binding protein

The Beclin 1 gene is a haplo-insufficient tumor suppressor and plays an essential role in autophagy. However, the molecular mechanism by which Beclin 1 functions remains largely unknown. Here we report the crysta...

Weijiao Huang, Wooyoung Choi, Wanqiu Hu, Na Mi, Qiang Guo, Meisheng Ma… in Cell Research (2012)