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  1. No Access

    Article

    Effect of mPEG-PLGA on Drug Crystallinity and Release of Long-Acting Injection Microspheres: In Vitro and In Vivo Perspectives

    Traditional progesterone (PRG) injections require long-term administration, leading to poor patient compliance. The emergence of long-acting injectable microspheres extends the release period to several days o...

    Dandan **ng, Lihua Tang, Hongyu Yang, Mingjiao Yan, Panao Yuan… in Pharmaceutical Research (2024)

  2. No Access

    Article

    Antibacterial-Anti-Inflammatory-Bone Restoration Procedure Achieved by MIN-Loaded PLGA Microsphere for Efficient Treatment of Periodontitis

    The main development process of periodontitis involves periodontal pathogenic bacteria as the initiating factor causing the onset of destructive inflammation, which in turn stimulates the destruction of period...

    Jiansong Zhao, Ying Wei, Jian **ong, Hongbing Liu, Gaoshuai Lv… in AAPS PharmSciTech (2023)

  3. No Access

    Article

    Progesterone Phospholipid Gel for Intramuscular Administration Prepared by In Situ-Phase Separation

    Long-term daily injection of progesterone for the treatment of threatened abortion can be a source of considerable pain to patients. To reduce the frequency of injections and improve patient compliance, a nove...

    Ning Dong, Lihua Tang, Meihui Zhao, Yingchao Zhang, Yu Zhang, Tian Yin… in AAPS PharmSciTech (2022)

  4. No Access

    Article

    Paclitaxel exposure-toxicity analysis reveals a pharmacokinetic determinant for dose-limiting neutropenia in East-Asian solid tumor patients: results from two prospective, phase II studies

    The time of a paclitaxel (PTX) concentration remains above 0.05 μM (Tc > 0.05) has been associated with PTX-induced adverse effects in Caucasians, while limited studies were reported in Asians. This study was ...

    **hui Xue, Haipeng He, Zuan Lin, Yuehan Wu… in Cancer Chemotherapy and Pharmacology (2022)

  5. No Access

    Article

    Alleviating the Influence of Circadian Rhythms and Drug Properties to the Release of Paliperidone Gel Matrix Tablets with Compression Coating Technology and Microenvironment Sha**

    The influence of circadian rhythms is an important content in oral dosage form study which is shown as different pH conditions and gastrointestinal dynamics in the gastrointestinal tract. The purpose of this s...

    Zherui Zhang, Shumin Chen, Man Wen, Haibing He, Yu Zhang, Tian Yin… in AAPS PharmSciTech (2022)

  6. No Access

    Article

    Construction and Evaluation of Traceable rhES-QDs-M-MS Protein Delivery System: Sustained-Release Properties, Targeted Effect, and Antitumor Activity

    Recombinant human endostatin (rhES) is a protein drug with poor stability and short in vivo circulation time. The present study was therefore aimed at develo** sustained-release lung targeted microspheres drug ...

    **aowen Wu, Yi Zou, Kunyu Du, Yi Du, Caleb Kesse Firempong, Yang Yu… in AAPS PharmSciTech (2022)

  7. No Access

    Article

    Evaluation of Emulsifying Ability of Phospholipids by Langmuir Monolayers and Stability of High Oil Ratio O/W Emulsions

    High oil ratio fat emulsion injections are prone to poor emulsification, rapid creaming, and other quality problems; therefore, the selection of emulsifiers with high emulsifying ability is crucial for the pro...

    Shanghui Li, Bing Zhang, Minsi Chang, Ruirong Zhang, Bei Liu, Tian Yin… in AAPS PharmSciTech (2022)

  8. No Access

    Article

    Chitosan-Coated Liposomes: The Strategy to Reduce Intestinal Toxicity and Improve Bioavailability of Oral Vinorelbine

    In recent years, the oral administration of vinorelbine has gradually replaced intravenous administration in the treatment of several types of tumors. Even though the risk of phlebitis is avoided with oral adm...

    Chen Guo, **chun Zhu, Haoyang Yuan, Haoyu Liu, Yu Zhang, Tian Yin… in AAPS PharmSciTech (2022)

  9. No Access

    Article

    Improved Core Viscosity Achieved by PDLLA10kCo-Incorporation Promoted Drug Loading and Stability of mPEG2k-b-PDLLA2.4k Micelles

    This study aims to investigate the effect of poly(D, L-lactic acid)10K (PDLLA10K) incorporation on the drug loading and stability of poly(ethylene glycol)2K-block-poly(D, L-lactide)2.4K (mPEG2k-b-PDLLA2.4k) micel...

    Chen Guo, Ying Zhang, Haoyang Yuan, Yu Zhang, Tian Yin… in Pharmaceutical Research (2022)

  10. No Access

    Article

    Preparation and Evaluation of rhINF-α-2b Sodium Hyaluronate Cross-Linked Porous Microspheres: Characterization, Sustained-Release Properties, and Antitumor Activity

    Recombinant human interferon α-2b (rhINF-α-2b), like most proteins, has several shortcomings such as relatively short half-life, low therapeutic index, high circulating drug fluctuations, and rapid degradation...

    Hongfei Liu, Yi Zou, Jie Zhu, Haibing He, Yingshu Feng… in AAPS PharmSciTech (2021)

  11. No Access

    Article

    Co-delivery of gemcitabine and cisplatin via Poly (L-glutamic acid)-g-methoxy poly (ethylene glycol) micelle to improve the in vivo stability and antitumor effect

    The intention of the study was to co-delivery gemcitabine and cisplatin with totally different nature by prodrug and micelle strategy to improve its in vivo stability and antitumor effect.

    Ning Ding, Zhiqing Zhao, Na Yin, Ying Xu, Tian Yin, **gxin Gou… in Pharmaceutical Research (2021)

  12. No Access

    Article

    Stable Atropine Loaded Film As a Potential Ocular Delivery System For Treatment Of Myopia

    The objective of the present study was to prepare stable and high bioavailability ocular atropine loaded films (ATR-films) as potential ocular drug delivery systems for the treatment of myopia.

    Muse Ji, Hongbing Liu, Shuting Ma, Jun Kong, Yannan Jia… in Pharmaceutical Research (2021)

  13. No Access

    Article

    Acute Diallyl Disulfide Administration Prevents and Reveres Lipopolysaccharide-Induced Depression-Like Behaviors in Mice via Regulating Neuroinflammation and Oxido-Nitrosative Stress

    Neuroinflammation and oxidative stress play critical roles in pathogenesis of depression. Diallyl disulfide (DADS), an active compound in garlic oil, has been shown to exhibit obvious anti-inflammatory and ant...

    **aoyou Wei, Yaoying Ma, Fu Li, Haiyan He, Huaxing Huang, Chao Huang… in Inflammation (2021)

  14. Article

    Open Access

    C4OH is a potential newborn screening marker—a multicenter retrospective study of patients with beta-ketothiolase deficiency in China

    Beta-ketothiolase deficiency (BKTD) is an autosomal recessive disorder caused by biallelic mutation of ACAT1 that affects both isoleucine catabolism and ketolysis. There is little information available regarding ...

    Yiming Lin, Zhantao Yang, Chiju Yang, Haili Hu… in Orphanet Journal of Rare Diseases (2021)

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  15. No Access

    Article

    Preparation of mPEG-b-PLA/TM-2 Micelle Lyophilized Products by Mixed Lyoprotectors and Antitumor Effect In Vivo

    The objective of this study was to encapsulate the poorly water-soluble drug TM-2 into polymer micelles using mPEG2k-b-PLA2.4k to increase its aqueous solubility and improve its therapeutic effect for liver cance...

    Ying Zhang, Yi Liu, Na Wang, Hongbing Liu, **gxin Gou, Haibing He… in AAPS PharmSciTech (2021)

  16. No Access

    Article

    Contrastive Studies of Cytarabine/Daunorubicin Dual-Loaded Liposomes Prepared by pH Gradient and Cu2+ Gradient Method

    Conventional combination chemotherapy often leads to unsatisfactory clinical outcomes due to the different distribution characteristics in vivo and the superimposed systemic toxicity of the drug cocktail. Co-enca...

    Jiaoyang Zhang, Lingli Zhou, Yu Zhang, Haibing He, Tian Yin… in AAPS PharmSciTech (2020)

  17. No Access

    Article

    In Vitro and In Vivo Evaluation of SP94 Modified Liposomes Loaded with N-14NCTDA, a Norcantharimide Derivative for Hepatocellular Carcinoma-Targeting

    The purpose of this research is to develop a liposomal drug delivery system, which can selectively target hepatocellular carcinoma (HCC) to deliver the antitumor agent N-14NCTDA, a C14 alkyl chain norcantharimide...

    Ying Jiang, **aolin Liu, **nyi Tan, Ye Hou, Wanxiao Sun, **gxin Gou… in AAPS PharmSciTech (2020)

  18. No Access

    Article

    Characterizing and Exploring the Differences in Dissolution and Stability Between Crystalline Solid Dispersion and Amorphous Solid Dispersion

    Solid dispersion is one of the most effective ways to improve the dissolution of insoluble drugs. When the carrier can highly disperse the drug, it will increase the wettability of the drug and reduce the surf...

    **aolin Wang, Lu Zhang, Danyang Ma, **ng Tang, Yu Zhang, Tian Yin… in AAPS PharmSciTech (2020)

  19. No Access

    Article

    A Novel Eyes Topical Drug Delivery System: CsA-LNC for the Treatment of DED

    The objective of the present work was to prepare safe and effective Ciclosporin A Lipid nanocapsule (CsA-LNC) eye-drops for the treatment of DED.

    Anan Zhang, Rong Sun, Meixin Ran, Yaxin Deng, Ying Ge… in Pharmaceutical Research (2020)

  20. No Access

    Article

    Aprepitant Intravenous Emulsion Based on Ion Pairing/Phospholipid Complex for Improving Physical and Chemical Stability During Thermal Sterilization

    An aprepitant (APT) cholesteryl hemisuccinate (CHEMS) ion pair complex emulsion (AIPE) with high lecithin content was prepared to improve sterilization stability through the film dispersion homogenization meth...

    **nyu Zhang, Ying Wei, Zhijun Cao, Ying Xu, Cong Lu, Meiqi Zhao… in AAPS PharmSciTech (2020)

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