15 Result(s)
within
H. Savolainen
Occupational Medicine/Industrial Medicine
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Article
Host factors in occupational diisocyanate asthma: a Swiss longitudinal study
Objective: To investigate the usefulness of surrogates for individual susceptibility to organic diisocyanates in occupational asthma. Subjects: All new cases declared to the Swiss National Accident Insurance Comp...
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Article
Urinary methanol and formic acid as indicators of occupational exposure to methyl formate
Objective: To evaluate the validity of methanol (MeOH) and formic acid (FA) in urine as biological indicators of methyl formate (MF) exposure in experimental and field situations. Methods: The subjects were 28 f...
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Article
Rat model for renal effects of 2-alkoxyalcohols and their acetates
Male Wistar rats were given ethanediol (9.4 g/l), 2-ethoxyethylacetate (5.4 g/l), 2-butoxyethylacetate (2.9 g/l) and 1,2-propanediol (40 g/l) respectively in their drinking water for 2 weeks. Urine was collec...
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Article
Urinary hexane diamine as an indicator of occupational exposure to hexamethylene diisocyanate
The occupational exposure of 19 men to hexamethylene diisocyanate (HDI) vapour was monitored during one 8-h shift. It ranged from 0.30 to 97.7 μg/m3. This was compared with the urinary output of hexane diamine (H...
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Article
Biological monitoring of occupational exposure to toluene diisocyanate
The study validated the use of urinary toluene diamine (TDA) in postshift samples as an indicator of preceding 8-h exposure to toluene diisocyanate (TDI). Nine workers exposed in TDI-based polyurethane foam pr...
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Article
Volatile metabolites in occupational exposure to organic sulfur compounds
Dimethyl sulfide in breath was determined by the gas chromatographic method in 14 persons exposed to organic reduced sulfur compounds in sulfate pulp mills. Dimethyl sulfide concentrations in breath (range 0.0...
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Article
Urinary arginine and ornithine in occupational exposure to 2-ethylhexanoic acid
Nine sawmill workers were divided into two groups according to their exposure to 2-ethylhexanoic acid, (EHA), a pesticide which has replaced the older pentochlorophenol. The men with lower exposure excreted 30...
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Article
2-Ethylhexanoic acid inhibits urea synthesis and stimulates carnitine acetyltransferase activity in rat liver mitochondria
Adult male 3-month-old Wistar rats were given 0, 100 mg/l, 1, 5 or 10 g/l 2-ethylhexanoic acid in their drinking water for 20 days. Their daily consumption of contaminated water was measured and compared with ...
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Article
Abstracts des communications et posters / Zusammenfassung der Vorträge und Poster
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Article
Biochemical effects of methyl tertiary-butyl ether in extended vapour exposure of rats
Male Wistar rats exposed to 50, 100 or 300 ppm methyl tertiary-butyl ether vapour for 2–15 weeks, 6 h daily, 5 days a week, showed a dose-dependent blood ether concentration after 2 weeks' exposure. Blood concent...
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Article
Morpholine vapour inhalation and interactions of simultaneous nitrite intake
Male Wistar rats exposed intermittently to 300 ppm (12.5 μmol/l) morpholine vapour 5 days a week for 6 h daily during 4–15 weeks displayed an increasing brain solvent content analyzed by a sensitive gas chroma...
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Article
Dose-dependent neurochemical changes during short-term inhalation exposure tom-xylene
Male Wistar rats were exposed tom-xylene vapor at concentrations of 2.0, 16.1, and 30.3 μmol/l for 2 weeks (5 days a week, 6 h daily). Xylene concentrations in brain and perirenal fat increased between weeks 1 an...
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Article
Cumulative biochemical effects of repeated subclinical hydrogen sulfide intoxication in mouse brain
Adult female NMRI mice exposed four times to 100 ppm hydrogen sulfide vapour for 2 h at 4-day intervals showed increasing inhibition of the cerebral cytochrome oxidase activity. Cerebral RNA decreased signific...
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Article
Biochemical and toxicological effects of short-term, intermittent xylene inhalation exposure and combined ethanol intake
Intermittent inhalation of 300 ppm of xylene vapour 6 h daily for 2 weeks caused a marked accumulation of the solvent in the perirenal fat. Simultaneous ethanol ingestion reduced the solvent load significantly...
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Article
Trichloroethylene and 1,1,1-trichloroethane: effects on brain and liver after five days intermittent inhalation
The inhalation exposure of adult male rats to 7.9 μmol/l (200 ppm) of trichloroethylene for 4 days 6 h each day led to an accumulation of the solvent in the perirenal fat 17 h after the last exposure. Exposure...
