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Neuropeptide S receptor gene — converging evidence for a role in panic disorder

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  1. Article

    Open Access

    The functional −1019C/G HTR1A polymorphism and mechanisms of fear

    Serotonin receptor 1A gene (HTR1A) knockout mice show pronounced defensive behaviour and increased fear conditioning to ambiguous conditioned stimuli. Such behaviour is a hallmark of pathological human anxiety, a...

    B Straube, A Reif, J Richter, U Lueken, H Weber, V Arolt… in Translational Psychiatry (2014)

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  2. Article

    Open Access

    MAOA gene hypomethylation in panic disorder—reversibility of an epigenetic risk pattern by psychotherapy

    Epigenetic signatures such as methylation of the monoamine oxidase A (MAOA) gene have been found to be altered in panic disorder (PD). Hypothesizing temporal plasticity of epigenetic processes as a mechanism of s...

    C Ziegler, J Richter, M Mahr, A Gajewska, M A Schiele… in Translational Psychiatry (2016)

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  3. Article

    Open Access

    Modulation of defensive reactivity by GLRB allelic variation: converging evidence from an intermediate phenotype approach

    Representing a phylogenetically old and very basic mechanism of inhibitory neurotransmission, glycine receptors have been implicated in the modulation of behavioral components underlying defensive responding t...

    U Lueken, M Kuhn, Y Yang, B Straube, T Kircher, H-U Wittchen… in Translational Psychiatry (2017)

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  4. Article

    Open Access

    A functional genetic variation of SLC6A2 repressor hsa-miR-579-3p upregulates sympathetic noradrenergic processes of fear and anxiety

    Increased sympathetic noradrenergic signaling is crucially involved in fear and anxiety as defensive states. MicroRNAs regulate dynamic gene expression during synaptic plasticity and genetic variation of micro...

    L. G. Hommers, J. Richter, Y. Yang, A. Raab, C. Baumann… in Translational Psychiatry (2018)

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