10 Result(s)
within
Gwen Falony
Infectious Diseases
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Article
Open AccessMicrobiome confounders and quantitative profiling challenge predicted microbial targets in colorectal cancer development
Despite substantial progress in cancer microbiome research, recognized confounders and advances in absolute microbiome quantification remain underused; this raises concerns regarding potential spurious associa...
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Article
Open AccessThe gut microbiota contributes to the pathogenesis of anorexia nervosa in humans and mice
Anorexia nervosa (AN) is an eating disorder with a high mortality. About 95% of cases are women and it has a population prevalence of about 1%, but evidence-based treatment is lacking. The pathogenesis of AN p...
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Article
Open AccessMicrobiome and metabolome features of the cardiometabolic disease spectrum
Previous microbiome and metabolome analyses exploring non-communicable diseases have paid scant attention to major confounders of study outcomes, such as common, pre-morbid and co-morbid conditions, or polypha...
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Article
Open AccessVariation and transmission of the human gut microbiota across multiple familial generations
Although the composition and functional potential of the human gut microbiota evolve over the lifespan, kinship has been identified as a key covariate of microbial community diversification. However, to date, ...
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Genome-wide associations of human gut microbiome variation and implications for causal inference analyses
Recent population-based1–4 and clinical studies5 have identified a range of factors associated with human gut microbiome variation. Murine quantitative trait loci6, human twin studies7 and microbiome genome-wide ...
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Quantitative microbiome profiling disentangles inflammation- and bile duct obstruction-associated microbiota alterations across PSC/IBD diagnoses
Recent work has highlighted the importance of confounder control in microbiome association studies1,2. For instance, multiple pathologies previously linked to gut ecosystem dysbiosis display concomitant changes i...
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Article
Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: a proof-of-concept exploratory study
Metabolic syndrome is characterized by a constellation of comorbidities that predispose individuals to an increased risk of develo** cardiovascular pathologies as well as type 2 diabetes mellitus1. The gut micr...
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The neuroactive potential of the human gut microbiota in quality of life and depression
The relationship between gut microbial metabolism and mental health is one of the most intriguing and controversial topics in microbiome research. Bidirectional microbiota–gut–brain communication has mostly be...
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Richness and ecosystem development across faecal snapshots of the gut microbiota
Faecal microbiota richness is considered a hallmark of gut health and stability. However, in healthy hosts, richness would primarily reflect the stage of ecosystem development through the gut, rather than comm...
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Article
Species–function relationships shape ecological properties of the human gut microbiome
Despite recent progress, the organization and ecological properties of the intestinal microbial ecosystem remain under-investigated. Here, using a manually curated metabolic module framework for (meta-)genomic...
