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Article
Open AccessEvaluation of vaccine candidates against Rhodococcus equi in BALB/c mice infection model: cellular and humoral immune responses
Rhodococcus equi (R. equi) is a zoonotic opportunistic pathogen that mainly causes fatal lung and extrapulmonary abscesses in foals and immunocompromised individuals. To date, no commercial vaccine against R. equ...
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Article
Open AccessAnxiety and sleep quality in patients receiving maintenance hemodialysis: multiple mediating roles of hope and family function
The objective of this cross-sectional study was to examine the extent of sleep quality among individuals undergoing maintenance hemodialysis (MHD) and to scrutinize whether hope and family function serve as me...
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Article
Open AccessSystemic delivery of oncolytic herpes virus using CAR-T cells enhances targeting of antitumor immuno-virotherapy
Recent studies have indicated that combining oncolytic viruses with CAR-T cells in therapy has shown superior anti-tumor effects, representing a promising approach. Nonetheless, the localized delivery method o...
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Article
Open AccessCorrection: Effect of extracorporeal shockwave therapy for rotator cuff tendinopathy: a systematic review and meta‑analysis
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Article
Open AccessActivation of the osteoblastic HIF-1α pathway partially alleviates the symptoms of STZ-induced type 1 diabetes mellitus via RegIIIγ
The hypoxia-inducible factor-1α (HIF-1α) pathway coordinates skeletal bone homeostasis and endocrine functions. Activation of the HIF-1α pathway increases glucose uptake by osteoblasts, which reduces blood glu...
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Article
High-Performance Ammonia Detection of Polymeric BaTiO3/Ti3C2Tx MXene Composite-Based Sensor for Gas Emission and Leakage
NH3 is a dangerous gas, posing significant threats to human health and the delicate equilibrium of the environment. It emerges as a primary contributor to the noxious gas emissions prevalent in the selective cata...
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Article
Open AccessDetermination of anthracnose (Colletotrichum fructicola) resistance mechanism using transcriptome analysis of resistant and susceptible pear (Pyrus pyrifolia)
Anthracnose, mainly caused by Colletotrichum fructicola, leads to severe losses in pear production. However, there is limited information available regarding the molecular response to anthracnose in pears.
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Article
Open AccessAssociation between metabolic score of visceral fat and carotid atherosclerosis in Chinese health screening population: a cross-sectional study
The metabolic score for visceral fat (METS-VF) quantifies the cumulative burden of visceral and intra-abdominal adipose tissues. However, the relationship between the METS-VF and carotid atherosclerosis (CAS) ...
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Article
Open AccessThe global distribution of the macrolide esterase EstX from the alpha/beta hydrolase superfamily
Macrolide antibiotics, pivotal in clinical therapeutics, are confronting resistance challenges mediated by enzymes like macrolide esterases, which are classified into Ere-type and the less studied Est-type. In...
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Article
Open AccessA feedback loop driven by H3K9 lactylation and HDAC2 in endothelial cells regulates VEGF-induced angiogenesis
Vascular endothelial growth factor (VEGF) is one of the most powerful proangiogenic factors and plays an important role in multiple diseases. Increased glycolytic rates and lactate accumulation are associated ...
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Article
Open AccessMulti-UAV pursuit-evasion gaming based on PSO-M3DDPG schemes
The sample data for reinforcement learning algorithms often exhibit sparsity and instability, making the training results susceptible to falling into local optima. Mini-Max-Multi-agent Deep Deterministic Polic...
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Article
Open AccessRemoval efficiency of restroom ventilation revisited for short-term evaluation
Ventilation efficiency or contaminant removal efficiency is often evaluated using the ratio between the concentrations in the exhaust air and the room air. This ratio does not truly represent the expectation o...
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Article
Open AccessIs systemic inflammation a missing link between cardiometabolic index with mortality? Evidence from a large population-based study
This study sought to elucidate the associations of cardiometabolic index (CMI), as a metabolism-related index, with all-cause and cardiovascular mortality among the older population. Utilizing data from the Na...
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Article
Open AccessMinimally invasive stabilization using screws and cement for acetabular metastatic tumor: a case report
The aim of this case report is to evaluate minimally invasive stabilization using screws and cement for acetabular metastatic tumor and summarize the indications and contraindications for minimally invasive st...
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Article
Open AccessAssociation between blood groups and myocardial injury after non-cardiac surgery: a retrospective cohort study
Blood group is a potential genetic element in coronary artery disease. Nevertheless, the relationship between different ABO blood groups and myocardial injury after non-cardiac surgery (MINS) is poorly underst...
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Article
Open AccessOptimization design of battery bracket for new energy vehicles based on 3D printing technology
Nowadays, what captures consumers' primary attention is how to purchase electric vehicles with long range and desirable price. Lightweight construction stands as one of the most effective approaches for prolon...
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Article
Open AccessEstablishment of a circRNA-regulated E3 ubiquitin ligase signature and nomogram to predict immunotherapeutic efficacy and prognosis in hepatocellular carcinoma
Hepatocellular carcinoma (HCC) is a common type of malignant tumor where the prognosis is dismal. Circular RNA (CircRNA) is a novel RNA that regulates downstream gene transcription and translation to influence...
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Article
Open AccessComparative study of percutaneous endoscopic lumbar decompression and traditional revision surgery in the treatment of symptomatic adjacent segment degeneration
The objective of this study is to evaluate and compare the surgical outcomes and complications of Percutaneous Endoscopic Lumbar Decompression (PELD) and traditional revision surgery in treating symptomatic Ad...
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Article
Open AccessEstablishment of orthotopic osteosarcoma animal models in immunocompetent rats through muti-rounds of in-vivo selection
Immunodeficient murine models are usually used as the preclinical models of osteosarcoma. Such models do not effectively simulate the process of tumorigenesis and metastasis. Establishing a suitable animal mod...
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Article
Open AccessInterfacing exogenous stents with human coronary artery by self-assembled coating: designs, functionalities and applications
Drug-eluting stents are a commonly used treatment for coronary artery disease. However, the coatings used in drug-eluting stents have some limitations such as poor biocompatibility and drug loading capacity. I...
