506 Result(s)

Article

Correction: lncRNA THAP7-AS1, transcriptionally activated by SP1 and post-transcriptionally stabilized by METTL3-mediated m6A modification, exerts oncogenic properties by improving CUL4B entry into the nucleus

Hai-Ting Liu, Yong-**n Zou, Wen-jie Zhu, Sen-Liu… in Cell Death & Differentiation (2024)

Article

Tagging large CNV blocks in wheat boosts digitalization of germplasm resources by ultra-low-coverage sequencing

The massive structural variations and frequent introgression highly contribute to the genetic diversity of wheat, while the huge and complex genome of polyploid wheat hinders efficient genoty** of abundant v...

Jianxia Niu, Wenxi Wang, Zihao Wang, Zhe Chen, **aoyu Zhang, Zhen Qin… in Genome Biology (2024)

Article

A pan-KRAS degrader for the treatment of KRAS-mutant cancers

KRAS mutations are highly prevalent in a wide range of lethal cancers, and these mutant forms of KRAS play a crucial role in driving cancer progression and conferring resistance to treatment. While there have bee...

Jie Yang, Qiao-Li Wang, Guan-Nan Wang, Jia-Cong Ye, Zi-Qian Li… in Cell Discovery (2024)

Article

Mobilization and activation of tumor-infiltrating dendritic cells inhibits lymph node metastasis in intrahepatic cholangiocarcinoma

Lymph node metastasis (LNM) facilitates distant tumor colonization and leads to the high mortality in patients with intrahepatic cholangiocarcinoma (ICC). However, it remains elusive how ICC cells subvert immu...

Bao-Ye Sun, Zhu-Tao Wang, Ke-Zhu Chen, Yang Song, **g-Fang Wu… in Cell Death Discovery (2024)

Article

Localized, highly efficient secretion of signaling proteins by migrasomes

Migrasomes, enriched with signaling molecules such as chemokines, cytokines and angiogenic factors, play a pivotal role in the spatially defined delivery of these molecules, influencing critical physiological ...

Haifeng Jiao, **aopeng Li, Ying Li, Yuting Guo, **aoyu Hu, Takami Sho… in Cell Research (2024)

Article

Retraction Note: PI3 kinase/Akt/HIF-1α pathway is associated with hypoxia-induced epithelial–mesenchymal transition in fibroblast-like synoviocytes of rheumatoid arthritis

Guo-Qing Li, Yu Zhang, Dan Liu, Ya-Yun Qian… in Molecular and Cellular Biochemistry (2024)

Article

TREM2 deficiency aggravates renal injury by promoting macrophage apoptosis and polarization via the JAK-STAT pathway in mice

The triggering receptor expressed on myeloid cells 2 (TREM2) is an immune receptor that affects cellular phenotypes by modulating phagocytosis and metabolism, promoting cell survival, and counteracting inflamm...

Yan Cui, Chao Chen, Zhouqi Tang, Wenjia Yuan, Kaiye Yue… in Cell Death & Disease (2024)

Article

Genome-wide identification and expression analysis of the KNOX family and its diverse roles in response to growth and abiotic tolerance in sweet potato and its two diploid relatives

KNOXs, a type of homeobox genes that encode atypical homeobox proteins, play an essential role in the regulation of growth and development, hormonal response, and abiotic stress in plants. However, the KNOX gene ...

Li-Cong Jia, Zi-Tong Yang, Li-Li Shang, Shao-Zhen He, Huan Zhang, Xu Li… in BMC Genomics (2024)

Article

Structural basis for recognition of 26RFa by the pyroglutamylated RFamide peptide receptor

The neuropeptide 26RFa, a member of the RF-amide peptide family, activates the pyroglutamylated RF-amide peptide receptor (QRFPR), a class A GPCR. The 26RFa/QRFPR system plays critical roles in energy homeosta...

Sanshan **, Shimeng Guo, Youwei Xu, **n Li, Canrong Wu, **nheng He… in Cell Discovery (2024)

Article

Molecular characterization and biofilm formation ability of Enterococcus faecium and Enterococcus faecalis bloodstream isolates from a Chinese tertiary hospital in Bei**g

To investigate the molecular characteristics and biofilm-forming ability of 116 Enterococcus faecium (Efm) and 72 Enterococcus faecalis (Efs) isolates obtained from patients with bloodstream infections (BSI) at a...

**g-xian Yang, Cun-wei Liu, Fu-wei Wu, Ling Zhu… in International Microbiology (2024)

Article

Peroxiredoxin I and II as novel therapeutic molecular targets in cervical cancer treatment through regulation of endoplasmic reticulum stress induced by bleomycin

Cervical cancer, significantly affecting women worldwide, often involves treatment with bleomycin, an anticancer agent targeting breast, ovarian, and cervical cancers by generating reactive oxygen species (ROS...

Hu-Nan Sun, Da-Yu Ma, **ao-Yu Guo, Ying-Ying Hao, Mei-Hua **… in Cell Death Discovery (2024)

Article

Fasting alleviates metabolic alterations in mice with propionyl-CoA carboxylase deficiency due to Pcca mutation

Propionic acidemia (PA), resulting from Pcca or Pccb gene mutations, impairs propionyl-CoA metabolism and induces metabolic alterations. While speculation exists that fasting might exacerbate metabolic crises in ...

Wentao He, Hannah Marchuk, Dwight Koeberl, Takhar Kasumov… in Communications Biology (2024)

Article

Isolation and expression analysis of cellulose synthase 3 (Ces3) genes from sugarcane (Saccharum officinarum L.)

Plant cellulose synthase is one of the important glycosyltransferases, which catalyzes the synthesis of the paracrystalline of H-bonded-β-(1,4)-glucose chains. This study isolated the cellulose synthase 3 (Ces3) ...

Cheng-Mei Huang, Kai-Chao Wu… in Chemical and Biological Technologies in Ag… (2024)

Article

Cathepsin K deficiency prevented stress-related thrombosis in a mouse FeCl₃ model

Exposure to chronic psychological stress (CPS) is a risk factor for thrombotic cardiocerebrovascular diseases (CCVDs). The expression and activity of the cysteine cathepsin K (CTSK) are upregulated in stressed...

Xueying **, Xueling Yue, Zhe Huang, **angkun Meng… in Cellular and Molecular Life Sciences (2024)

Article

Map** and characterization of rust resistance genes Lr53 and Yr35 introgressed from Aegilops species

The rust resistance genes Lr53 and Yr35 were introgressed into bread wheat from Aegilops longissima or Aegilops sharonensis or their S-genome containing species and mapped to the telomeric region of chromosome ar...

Binyang Xu, Tao Shen, Hong Chen, Hongna Li… in Theoretical and Applied Genetics (2024)

Article

Orthogonal multimodality integration and clustering in single-cell data

Multimodal integration combines information from different sources or modalities to gain a more comprehensive understanding of a phenomenon. The challenges in multi-omics data analysis lie in the complexity, h...

Yufang Liu, Yongkai Chen, Haoran Lu, Wenxuan Zhong, Guo-Cheng Yuan… in BMC Bioinformatics (2024)

Article

Genetic and phenotypic analysis of 225 Chinese children with developmental delay and/or intellectual disability using whole-exome sequencing

Developmental delay (DD), or intellectual disability (ID) is a very large group of early onset disorders that affects 1–2% of children worldwide, which have diverse genetic causes that should be identified. Ge...

Heqian Ma, Lina Zhu, **ao Yang, Meng Ao, Shunxiang Zhang, Meizhen Guo… in BMC Genomics (2024)

Article

High-content method for mechanosignaling studies using IsoStretcher technology and quantitative Ca²⁺ imaging applied to Piezo1 in cardiac HL-1 cells

The importance of mechanosensory transduction pathways in cellular signalling has prominently come to focus in the last decade with the discovery of the Piezo ion channel family. Mechanosignaling involving Pie...

Anna-Lena Merten, Ulrike Schöler, Yang Guo… in Cellular and Molecular Life Sciences (2024)

Article

Correction: LncRNA SNHG1 and RNA binding protein hnRNPL form a complex and coregulate CDH1 to boost the growth and metastasis of prostate cancer

**ao Tan, Wen-bin Chen, Dao-jun Lv, Tao-wei Yang, Kai-hui Wu… in Cell Death & Disease (2024)

Article

Arnicolide D induces endoplasmic reticulum stress-mediated oncosis via ATF4 and CHOP in hepatocellular carcinoma cells

Endoplasmic reticulum (ER) stress can trigger various cell death mechanisms beyond apoptosis, providing promise in cancer treatment. Oncosis, characterized by cellular swelling and increased membrane permeabil...

Yu-Shan Lin, Zhiwei Sun, Li-Sha Shen, Rui-Hong Gong, Jia-Wen Chen… in Cell Death Discovery (2024)