215 Result(s)
within
Guo-**n Jiang
Life Sciences
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Article
Open AccessTREM2 deficiency aggravates renal injury by promoting macrophage apoptosis and polarization via the JAK-STAT pathway in mice
The triggering receptor expressed on myeloid cells 2 (TREM2) is an immune receptor that affects cellular phenotypes by modulating phagocytosis and metabolism, promoting cell survival, and counteracting inflamm...
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Open AccessStructural basis for recognition of 26RFa by the pyroglutamylated RFamide peptide receptor
The neuropeptide 26RFa, a member of the RF-amide peptide family, activates the pyroglutamylated RF-amide peptide receptor (QRFPR), a class A GPCR. The 26RFa/QRFPR system plays critical roles in energy homeosta...
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SHP-1 inhibition targets leukaemia stem cells to restore immunosurveillance and enhance chemosensitivity by metabolic reprogramming
Leukaemia stem cells (LSCs) in acute myeloid leukaemia present a considerable treatment challenge due to their resistance to chemotherapy and immunosurveillance. The connection between these properties in LSCs...
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Fungal diversity notes 1717–1817: taxonomic and phylogenetic contributions on genera and species of fungal taxa
As the continuation of Fungal Diversity Notes series, the current paper is the 16th contribution to this series. A total of 103 taxa from seven classes in Ascomycota and Basidiomycota are included here. Of these ...
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Open AccessComprehensive genomic profiling of breast cancers characterizes germline-somatic mutation interactions mediating therapeutic vulnerabilities
Germline-somatic mutation interactions are universal and associated with tumorigenesis, but their role in breast cancer, especially in non-Caucasians, remains poorly characterized. We performed large-scale pro...
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Identification and Analysis of Characteristic Flavour Compounds in Baked Potato of Different Cultivars Based on HS-GC-IMS
In this study, the volatile flavour compounds of baked potatoes from different cultivars were identified and analysed via headspace–gas chromatography–ion mobility spectrometry (HS-GC-IMS) together with princi...
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Open AccessGenetic diversity of field Fusarium asiaticum and Fusarium graminearum isolates increases the risk of fungicide resistance
Fusarium head blight (FHB) caused by Fusarium species, seriously threatens the safety of wheat (Triticum aestivum) production. Resistant cultivars and fungicides are frequently used to control these FHB pathogens...
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Open AccessThe pseudoenzyme ADPRHL1 affects cardiac function by regulating the ROCK pathway
Pseudoenzymes, catalytically deficient variants of active enzymes, have a wide range of regulatory functions. ADP-ribosylhydrolase-like 1 (ADPRHL1), a pseudoenzyme belonging to a small group of ADP-ribosylhydr...
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Open AccessLysine butyrylation of HSP90 regulated by KAT8 and HDAC11 confers chemoresistance
Posttranslational modification dramatically enhances protein complexity, but the function and precise mechanism of novel lysine acylation modifications remain unknown. Chemoresistance remains a daunting challe...
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Article
A positively tuned voltage indicator for extended electrical recordings in the brain
Genetically encoded voltage indicators (GEVIs) enable optical recording of electrical signals in the brain, providing subthreshold sensitivity and temporal resolution not possible with calcium indicators. Howe...
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Article
Prolonged hypoxia alleviates prolyl hydroxylation-mediated suppression of RIPK1 to promote necroptosis and inflammation
The prolyl hydroxylation of hypoxia-inducible factor 1α (HIF-1α) mediated by the EGLN–pVHL pathway represents a classic signalling mechanism that mediates cellular adaptation under hypoxia. Here we identify RI...
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Open AccessWidely targeted quantitative lipidomics and prognostic model reveal plasma lipid predictors for nasopharyngeal carcinoma
Dysregulation of lipid metabolism is closely associated with cancer progression. The study aimed to establish a prognostic model to predict distant metastasis-free survival (DMFS) in patients with nasopharynge...
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Open AccessEnhancer-driven transcription of MCM8 by E2F4 promotes ATR pathway activation and glioma stem cell characteristics
Glioma stem cells (GSCs) are responsible for glioma recurrence and drug resistance, yet the mechanisms underlying their maintenance remains unclear. This study aimed to identify enhancer-controlled genes invol...
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Open AccessElevated Interleukin-37 Associated with Dengue Viral Load in Patients with Dengue Fever
Dengue remains a public health issue worldwide. Similar to chronic infectious diseases, stimulation of cytokine production is not enough to drive immune effector cells for effective virus clearance. One possib...
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Transcriptomic-based analysis to identify candidate genes for blue color rose breeding
Analysis of the flower color formation mechanism of ‘Rhapsody in Blue’ by BF and WF transcriptomes reveals that RhF3’H and RhGT74F2 play a key role in flower color formation.
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Open AccessMetavirome of 31 tick species provides a compendium of 1,801 RNA virus genomes
The increasing prevalence and expanding distribution of tick-borne viruses globally have raised health concerns, but the full repertoire of the tick virome has not been assessed. We sequenced the meta-transcri...
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Open AccessCorrection: Acinar ATP8b1/LPC pathway promotes macrophage efferocytosis and clearance of inflammation during chronic pancreatitis development
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Open AccessAcinar ATP8b1/LPC pathway promotes macrophage efferocytosis and clearance of inflammation during chronic pancreatitis development
Noninflammatory clearance of dying cells by professional phagocytes, termed efferocytosis, is fundamental in both homeostasis and inflammatory fibrosis disease but has not been confirmed to occur in chronic pa...
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Article
Siccirubricoccus soli sp. nov., a novel bacterial species isolated from Jiaozi Mountain soil
An isolate of Gram-stain-negative and strictly aerobic bacterium, designated KC 17139T, was isolated from Jiaozi Mountain sample in Yunnan, China. Cells were non-motile cocci to oval, catalase-positive and oxidas...
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Article
Microcella aerolata sp. nov., isolated from electronic waste-associated bioaerosols
A Gram-positive, non-motile, non-spore-forming and short rod-shaped actinomycete strain, designated GA224T, was isolated from electronic waste-associated bioaerosols. The optimal growth conditions for this isolat...
