37 Result(s)
within
Guo-**g Hai
Science, Humanities and Social Sciences, multidisciplinary
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Article
Open AccessUnique physiological and pathogenic features of Leptospira interrogans revealed by whole-genome sequencing
Leptospirosis is a widely spread disease of global concern. Infection causes flu-like episodes with frequent severe renal and hepatic damage, such as haemorrhage and jaundice. In more severe cases, massive pul...
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Article
The role of Tet3 DNA dioxygenase in epigenetic reprogramming by oocytes
The paternal genome in a zygote undergoes active DNA demethylation before the fusion of the male and female pronuclei, and this coincides with oxidation of 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (...
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Article
Open AccessLong-term strain improvements accumulate mutations in regulatory elements responsible for hyper-production of cellulolytic enzymes
Long-term strain improvements through repeated mutagenesis and screening have generated a hyper-producer of cellulases and hemicellulases from Penicillium decumbens 114 which was isolated 30 years ago. Here, the ...
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Article
Open AccessDual-Targeting Pro-apoptotic Peptide for Programmed Cancer Cell Death via Specific Mitochondria Damage
Mitochondria are vital organelles to eukaryotic cells. Damage to mitochondria will cause irreversible cell death or apoptosis. In this report, we aim at programmed cancer cell death via specific mitochondrial ...
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Article
Open AccessIRF8 suppresses pathological cardiac remodelling by inhibiting calcineurin signalling
Interferon regulatory factor 8 (IRF8) is known to affect the innate immune response, for example, by regulating the differentiation and function of immune cells. However, whether IRF8 can influence cardiac hyp...
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Open AccessA ‘Clicked’ Tetrameric Hydroxamic Acid Glycopeptidomimetic Antagonizes Sugar-Lectin Interactions On The Cellular Level
A tetrameric N-acetyl galactosaminyl (GalNAc) peptidomimetic was constructed by N-acetylation of repeating proline-based hydroxamic acid units, followed by a convergent ‘click chemistry’ coupling. This novel glyc...
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Article
Open AccessMultifunctional Enveloped Mesoporous Silica Nanoparticles for Subcellular Co-delivery of Drug and Therapeutic Peptide
A multifunctional enveloped nanodevice based on mesoporous silica nanoparticle (MSN) was delicately designed for subcellular co-delivery of drug and therapeutic peptide to tumor cells. Mesoporous silica MCM-41...
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Article
Open AccessThe complex jujube genome provides insights into fruit tree biology
The jujube (Ziziphus jujuba Mill.), a member of family Rhamnaceae, is a major dry fruit and a traditional herbal medicine for more than one billion people. Here we present a high-quality sequence for the complex ...
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Article
Open AccessAcidic phospholipids govern the enhanced activation of IgG-B cell receptor
B cells that express the isotype-switched IgG-B cell receptor (IgG-BCR) are one of the driving forces for antibody memory. To allow for a rapid memory IgG antibody response, IgG-BCR evolved into a highly effec...
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Article
Open AccessQuasi-steady-state air plasma channel produced by a femtosecond laser pulse sequence
A long air plasma channel can be formed by filamentation of intense femtosecond laser pulses. However, the lifetime of the plasma channel produced by a single femtosecond laser pulse is too short (only a few n...
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Article
Open AccessCombined experimental and computational study of high-pressure behavior of triphenylene
We have performed measurements of Raman scattering, synchrotron x-ray diffraction and visible transmission spectroscopy combined with density functional theory calculations to study the pressure effect on soli...
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Article
Open AccessAcetate functions as an epigenetic metabolite to promote lipid synthesis under hypoxia
Besides the conventional carbon sources, acetyl-CoA has recently been shown to be generated from acetate in various types of cancers, where it promotes lipid synthesis and tumour growth. The underlying mechani...
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Article
Open AccessPotentials of the elevated circulating miR-185 level as a biomarker for early diagnosis of HBV-related liver fibrosis
Early diagnosis of liver fibrosis is critical for early intervention and prognosis of various chronic liver diseases. Conventional repeated histological assessment is impractical due to the associated invasive...
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Article
TET-mediated DNA demethylation controls gastrulation by regulating Lefty–Nodal signalling
Inactivation of three Tet genes in mice leads to gastrulation phenotypes similar to those in embryos with increased Nodal signalling, revealing a functional redundancy of Tet genes and showing balanced and dynami...
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Article
Open AccessFunctional variants of the 5-methyltetrahydrofolate-homocysteine methyltransferase gene significantly increase susceptibility to prostate cancer: Results from an ethnic Han Chinese population
Aberrant DNA methylation has been implicated in prostate carcinogenesis. The one-carbon metabolism pathway and related metabolites determine cellular DNA methylation and thus is thought to play a pivotal role ...
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Article
Open AccessMTHFR c.677C>T Inhibits Cell Proliferation and Decreases Prostate Cancer Susceptibility in the Han Chinese Population in Shanghai
Methylenetetrahydrofolate reductase (MTHFR) c.677C>T and c.1298A>C variants were known to be associated with prostate cancer (PCa) risk with conflicting results, because of MTHFR and nutrient status interaction i...
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Article
Open AccessWater-soluble acacetin prodrug confers significant cardioprotection against ischemia/reperfusion injury
The morbidity and mortality of patients with ischemic cardiomyopathy resulted from ischemia/reperfusion injury are very high. The present study investigates whether our previously synthesized water-soluble pho...
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Article
Open AccessEvolution of structural distortion in BiFeO3 thin films probed by second-harmonic generation
BiFeO3 thin films have drawn much attention due to its potential applications for novel magnetoelectric devices and fundamental physics in magnetoelectric coupling. However, the structural evolution of BiFeO3 fil...
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Article
Open AccessStatus of HBsAg seroprevalence in 15 million rural couples in China: a cross-sectional study
A cross-sectional analysis of prevalence of hepatitis B virus infection (HBV) among rural couples was conducted between 2010 and 2014. Serologic HBV markers, including hepatitis B surface antigen (HBsAg) and e...
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Article
Open AccessEffective Removal of Tetracycline Antibiotics from Water using Hybrid Carbon Membranes
Antibiotic residues in drinking water have become a global problem, especially in develo** countries. However, effective purification of water contaminated by antibiotics remains a great challenge. Here, we ...
