-
Article
Open AccessTargeting delivery of miR-146a via IMTP modified milk exosomes exerted cardioprotective effects by inhibiting NF-κB signaling pathway after myocardial ischemia-reperfusion injury
Reperfusion therapy is critical for saving heart muscle after myocardial infarction, but the process of restoring blood flow can itself exacerbate injury to the myocardium. This phenomenon is known as myocardi...
-
Article
Improving RSW nugget diameter prediction method: unleashing the power of multi-fidelity neural networks and transfer learning
This research presents an innovative approach to accurately predict the nugget diameter in resistance spot welding (RSW) by leveraging machine learning and transfer learning methods. Initially, low-fidelity (L...
-
Article
Innovative coaxial high-temperature thin-film sensor with core–shell structure surpassing traditional multilayer films
High-temperature thin-film sensors (TFSs) often suffer from inadequate tolerance to elevated temperatures. In this study, an innovative approach is presented to fabricate in situ integrated TFSs with a core–sh...
-
Article
Ruthenium–dihydroartemisinin complex: a promising new compound for colon cancer prevention via G1 cell cycle arrest, apoptotic induction, and adaptive immune regulation
Artemisinin (ART) and its derivatives are important antimalaria agents and have received increased attention due to their broad biomedical effects, such as anticancer and anti-inflammation activities. Recently...
-
Article
Open AccessWnt5a/β-catenin-mediated epithelial-mesenchymal transition: a key driver of subretinal fibrosis in neovascular age-related macular degeneration
Neovascular age-related macular degeneration (nAMD), accounts for up to 90% of AMD-associated vision loss, ultimately resulting in the formation of fibrotic scar in the macular region. The pathogenesis of subr...
-
Article
Open AccessTransarterial Chemoembolization with Epirubicin-Loaded Microspheres for Hepatocellular Carcinoma: A Prospective, Single-Arm, Multicenter, Phase 2 Study (STOPPER Trial)
While the role of drug-eluting beads transarterial chemoembolization (DEB-TACE) for hepatocellular carcinoma (HCC) is established, questions regarding appropriate bead size for use in patients remain. This tri...
-
Article
Open AccessImmune persistence after different polio sequential immunization schedules in Chinese infants
Trivalent oral poliovirus vaccine (tOPV) has been withdrawn and instead an inactivated poliovirus vaccine (IPV) and bivalent type 1 and type 3 OPV (bOPV) sequential immunization schedule has been implemented s...
-
Article
Open AccessSynthesis and superconductivity in yttrium-cerium hydrides at high pressures
Further increasing the critical temperature and/or decreasing the stabilized pressure are the general hopes for the hydride superconductors. Inspired by the low stabilized pressure associated with Ce 4f electrons...
-
Article
Arterial chemotherapy for hepatocellular carcinoma in China: consensus recommendations
Hepatocellular carcinoma (HCC) is one of the most common malignancies and the third leading cause of cancer-related deaths globally. Hepatic arterial infusion chemotherapy (HAIC) treatment is widely accepted a...
-
Article
Lithium-induced graphene layer containing Li3P alloy phase to achieve ultra-stable electrode interface for lithium metal anode
Uncontrolled growth of lithium dendrite will lead to low Coulombic efficiency and poor cycle stability, which hinders the commercialization of lithium metal batteries. Herein, a novel modified lithium anode wi...
-
Article
Open AccessMacro CD5L+ deteriorates CD8+T cells exhaustion and impairs combination of Gemcitabine-Oxaliplatin-Lenvatinib-anti-PD1 therapy in intrahepatic cholangiocarcinoma
Intratumoral immune status influences tumor therapeutic response, but it remains largely unclear how the status determines therapies for patients with intrahepatic cholangiocarcinoma. Here, we examine the sing...
-
Chapter and Conference Paper
Soft Actor-Critic Based Deep Reinforcement Learning Method for Production Optimization
Production optimization is a crucial technology for efficient development of water-driven reservoirs. By adjusting the injection and production rate of oil and water wells in a reservoir block, the optimal pro...
-
Article
Open AccessReal-world efficacy and safety of TACE plus camrelizumab and apatinib in patients with HCC (CHANCE2211): a propensity score matching study
This study aimed to investigate the efficacy and safety of transarterial chemoembolization (TACE) plus camrelizumab, a monoclonal antibody targeting programmed death-1, and apatinib for patients with intermedi...
-
Article
Open AccessSTING activation in TET2-mutated hematopoietic stem/progenitor cells contributes to the increased self-renewal and neoplastic transformation
Somatic loss-of-function mutations of the dioxygenase Ten-eleven translocation-2 (TET2) occur frequently in individuals with clonal hematopoiesis (CH) and acute myeloid leukemia (AML). These common hematopoiet...
-
Article
Open AccessFollicle-stimulating hormone orchestrates glucose-stimulated insulin secretion of pancreatic islets
Follicle-stimulating hormone (FSH) is involved in mammalian reproduction via binding to FSH receptor (FSHR). However, several studies have found that FSH and FSHR play important roles in extragonadal tissue. H...
-
Article
Simulation of gas–solid flow in sinter vertical cooling furnace
The velocity distribution of sinter and gas in vertical cooling furnace (VCF) has an important influence on gas–solid heat transfer. Based on the slot model of single hopper in the VCF of Meishan Iron and Stee...
-
Article
Exact solutions of the Schrödinger equation with a complex periodic potential
The exact solutions of 1D Schrödinger equation subject to a complex periodic potential \(V(x)=-[i\,a\,\sin (b\,x)+c]^2\) ...
-
Article
Quantitative algorithm for airborne gamma spectrum of large sample based on improved shuffled frog lea**–particle swarm optimization convolutional neural network
In airborne gamma ray spectrum processing, different analysis methods, technical requirements, analysis models, and calculation methods need to be established. To meet the engineering practice requirements of ...
-
Article
Open AccessProteogenomics of clear cell renal cell carcinoma response to tyrosine kinase inhibitor
The tyrosine kinase inhibitor (TKI) Sunitinib is one the therapies approved for advanced renal cell carcinoma. Here, we undertake proteogenomic profiling of 115 tumors from patients with clear cell renal cell ...
-
Article
Open AccessPathogenesis of miR-155 on nonmodifiable and modifiable risk factors in Alzheimer’s disease
Alzheimer’s disease (AD) is a common age-related neurodegenerative disease in the central nervous system and is the primary cause of dementia. It is clinically characterized by the memory impairment, aphasia, ...
