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Article
E2F1 Facilitates the Proliferation and Stemness of Gastric Cancer Cells by Activating CDC25B Transcription and Modulating the MAPK Pathway
Gastric cancer (GC) is a health problem that concerns people around the world. CDC25B is an essential cell cycle regulatory factor that is overexpressed in a variety of tumor cells. CDC25B plays a vital part i...
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Article
Parameter estimation of fractional uncertain differential equations
Fractional uncertain differential equations are used for forecast in this paper. It is crucial to provide an accurate estimation method since fractional uncertain differential equations hold memory effects and...
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Article
Open AccessDietary protein sources, gut microbiome, and puberty timing in children: findings from a cohort study
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Article
Characteristics and Formation Mechanism of Oxide–Sulfide Complex Inclusions in High-Speed Railway Wheel Steel
The deleterious effects of brittle and rigid oxides on the quality of high-speed railway wheel steel can be mitigated by wrap** the oxides with sulfides. The investigation reveals the presence of three types...
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Article
Numerical and Physical Simulation of Mixing Process in Argon-Stirred Ladles with Single and Dual Bottom Injection
A combined method including numerical and physical simulations has been employed to investigate the influence of nozzle arrangement and flow rate on the mixing effect and flow pattern within a 100-ton industri...
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Article
Characterization of a Homeodomain-Leucine Zipper Gene 12: Gene Silencing in Pepper and Arabidopsis-Based Overexpression During Abiotic Stress
Homeodomain-Leucine Zipper (HD-Zip) proteins are important ubiquitous and diverse molecular chaperones in plants. We characterized a gene CaATHB-12 derived from HD-Zip I subfamily which was intensively induced by...
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Article
Open AccessClinical characteristics and outcomes of acute liver failure in neonates: a retrospective cohort in China
Neonatal acute liver failure (NALF), as a rare disease with high mortality, has limited relevant literature reports in China. We attempted to analyze a NALF cohort to improve the prognosis of this disease. We ...
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Article
Open AccessOrthogonal multimodality integration and clustering in single-cell data
Multimodal integration combines information from different sources or modalities to gain a more comprehensive understanding of a phenomenon. The challenges in multi-omics data analysis lie in the complexity, h...
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Article
Open AccessPostoperative serum mir-28-5p level has predictive value for the prognosis after endovascular abdominal aortic aneurysm repair
We explored the clinical significance of miR-28-5p pre- and post-endovascular abdominal aortic aneurysm repair (EVAR) in abdominal aortic aneurysm (AAA) patients.
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Article
Response of organic acid metabolism in the young and ripening grape berries in vitro to ambient temperature
Organic acids, the important flavor compounds in grape berries, are altered by temperature during berry development. To mitigate potential interference encountered in field experiments, we employed in vitro cu...
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Article
Exogenous modification of EL-4 T cell extracellular vesicles with miR-155 induce macrophage into M1-type polarization
Extracellular vesicles (EVs) show promising potential to be used as therapeutics, disease biomarkers, and drug delivery vehicles. We aimed to modify EVs with miR-155 to modulate macrophage immune response that ca...
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Article
Open AccessLong-term exposure to ambient PM2.5 and its components on menarche timing among Chinese adolescents: evidence from a representative nationwide cohort
Ambient air pollutants have been suggested to affect pubertal development. Nevertheless, current studies indicate inconsistent effects of these pollutants, causing precocious or delayed puberty onset. This stu...
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Article
Open AccessAnalysis of Breast Cancer Screening Results and Influencing Factors of Breast Cancer in Guangdong Province from 2017 to 2021
Breast cancer screening plays an important role in the early detection, diagnosis and treatment of breast cancer. The aim of this study was to evaluate the screening results and explore the influencing factors...
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Article
Open AccessConvolutional neural network applied to preoperative venous-phase CT images predicts risk category in patients with gastric gastrointestinal stromal tumors
The risk category of gastric gastrointestinal stromal tumors (GISTs) are closely related to the surgical method, the scope of resection, and the need for preoperative chemotherapy. We aimed to develop and vali...
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Article
Open AccessMatrin3 mediates differentiation through stabilizing chromatin loop-domain interactions and YY1 mediated enhancer-promoter interactions
Although emerging evidence indicates that alterations in proteins within nuclear compartments elicit changes in chromosomal architecture and differentiation, the underlying mechanisms are not well understood. ...
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Article
Open AccessRadiomics analysis of contrast-enhanced computerized tomography for differentiation of gastric schwannomas from gastric gastrointestinal stromal tumors
To assess the performance of radiomics-based analysis of contrast-enhanced computerized tomography (CE-CT) images for distinguishing GS from gastric GIST.
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Article
An unsupervised mechanical fault classification method under the condition of unknown number of fault types
This paper proposes a novel unsupervised classification method to solve the problem of mechanical fault diagnosis under the condition of unknown number of fault types. The proposed method combining the three d...
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Article
Evolution Mechanism of Pore Structures of Organic-Rich Shale Under Tectonic Deformation: A Comparative Study Between Whole Rock and Kerogen Samples
Under tectonic stresses, shale in different stress–strain environments will undergo structural deformation of varying mechanisms and intensities, forming various types of tectonically deformed shales (TDSs). B...
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Article
As-Cast Grain Refinement of H13 Steel by Cerium Sulfide Formed During Solidification
The cerium sulfide (Ce–S) formed during solidification is used as the heterogeneous nucleation core to refine the as-cast grains. A mathematical model is established to predict the formation of Ce–S, and the m...
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Article
Transcription factor E2F3 activates CDC25B to regulate DNA damage and promote mitoxantrone resistance in stomach adenocarcinoma
CDC25B, as a member of the cell cycle regulating protein family, is located in the cytoplasm and is involved in the transition of the cell cycle and mitosis. CDC25B is highly expressed in various tumors and is...
