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Natural product-based screening led to the discovery of a novel PXR agonist with anti-cholestasis activity

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  1. Article

    Open Access

    New halimane and clerodane diterpenoids from Croton cnidophyllus

    Three new halimane furanoditerpenoids (13) and three new clerodane furanoditerpenoids (46), along with seven known terpenoids including four pimarane diterpenoids (710) and three norisoprenoids (1113) were is...

    Xun Wei, Jia-Luo Huang, Hua-Hua Gao, Fang-Yu Yuan in Natural Products and Bioprospecting (2023)

  2. Article

    Open Access

    Five new limonoids isolated from Walsura robusta

    Five new toosendanin limonoids with highly oxidative furan ring walsurobustones A-D (1–4), and one new furan ring degraded limonoid walsurobustone E (5) together with one known compound toonapubesic acid B (6) we...

    Li Hou, Cui-Xuan Mei, Chun-Mao Yuan, Gui-Hua Tang in Natural Products and Bioprospecting (2023)

  3. Article

    Open Access

    Mulberry Diels–Alder-type adducts: isolation, structure, bioactivity, and synthesis

    Mulberry Diels–Alder-type adducts (MDAAs) are unique phenolic natural products biosynthetically derived from the intermolecular [4 + 2]-cycloaddition of dienophiles (mainly chalcones) and dehydroprenylphenol d...

    Si-Yuan Luo, Jun-Yu Zhu, Ming-Feng Zou, Sheng Yin in Natural Products and Bioprospecting (2022)

  4. Article

    Open Access

    Psiguajadials A–K: Unusual Psidium Meroterpenoids as Phosphodiesterase-4 Inhibitors from the Leaves of Psidium guajava

    Bioassay-guided fractionation of the ethanolic extract of the leaves of Psidium guajava led to the isolation of 11 new Psidium meroterpenoids, psiguajadials A–K (111), along with 17 known ones (1228). Their str...

    Gui-Hua Tang, Zhen Dong, Yan-Qiong Guo, Zhong-Bin Cheng, Chu-Jun Zhou in Scientific Reports (2017)

  5. Article

    Open Access

    Two new tirucallane triterpenoids from Aphanamixis grandifolia

    Two new tirucallane triterpenoids, 2 α-ethoxy-2,3-secotirucalla-2,29-epoxy-7-ene-23-oxo-3-oic acid (1) and (23E)-2 α-hydroxytirucalla-7,23,25-triene-3-one (2), along with the known 2,3-secotirucalla-2,3;2,29-diep...

    **ao-Ying Wang, Gui-Hua Tang, Chun-Mao Yuan in Natural Products and Bioprospecting (2012)

  6. Article

    Open Access

    Limonoids and triterpenoids from the twigs and leaves of Dysoxylum hainanense

    Four new limonoids, dysohainanins A–D (1–4), and two new triterpenoids, dysohainanins E and F (5 and 6), together with seven known ones were isolated from the twigs and leaves of Dysoxylum hainanense Merr. The st...

    Wen-**ng Liu, Gui-Hua Tang, Hong-** He, Yu Zhang in Natural Products and Bioprospecting (2012)