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    Natural product-based screening led to the discovery of a novel PXR agonist with anti-cholestasis activity

    Cholestasis is a major cause of a series of bile flow malfunction-related liver diseases. Pregnane X receptor (PXR) is a key regulator in endo- and xeno-biotics metabolism, which has been considered as a promi...

    Dong Huang, Ying-yuan Zhao, Rui-min Wang, Wei Li in Acta Pharmacologica Sinica (2022)