1,079 Result(s)
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Gong-** Cheng
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Article
Brain-Targeting Emodin Mitigates Ischemic Stroke via Inhibiting AQP4-Mediated Swelling and Neuroinflammation
Failure to achieve target-specific delivery to ischemic brain sites has hampered the clinical efficacy of newly developed therapies for ischemic stroke. Emodin, an active ingredient isolated from traditional C...
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Open AccessMeasurement of e+e− → ωη′ cross sections at \( \sqrt{s} \) = 2.000 to 3.080 GeV
We measured the Born cross sections for the process e+e− → ωη′ at 22 center-of-mass energies from 2.000 to 3.080 GeV with the BESIII detector at the BEPCII collider. We observed a resonant structure with a statis...
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Open AccessWhole exome sequencing analysis identifies genes for alcohol consumption
Alcohol consumption is a heritable behavior seriously endangers human health. However, genetic studies on alcohol consumption primarily focuses on common variants, while insights from rare coding variants are ...
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Elevational distribution of forests and its spatiotemporal dynamics in subtropical China from 2000 to 2019
The subtropical region of China possesses abundant forest resources and features a mountainous terrain. Under the implementation of policies such as natural forest protection, the Grain for Green Project, and ...
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GSTO1 aggravates EGFR-TKIs resistance and tumor metastasis via deglutathionylation of NPM1 in lung adenocarcinoma
Despite significantly improved clinical outcomes in EGFR-mutant lung adenocarcinoma, all patients develop acquired resistance and malignancy on the treatment of EGFR tyrosine kinase inhibitors (EGFR-TKIs). Und...
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Open AccessPopulation genetic structure of Culex tritaeniorhynchus in different types of climatic zones in China
Culex tritaeniorhynchus is widely distributed in China, from Hainan Island in the south to Heilongjiang in the north, covering tropical, subtropical, and temperate climate zones. Culex tritaeniorhynchus carries 1...
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Open AccessDesigned wrinkles for optical encryption and flexible integrated circuit carrier board
Patterns on polymers usually have different mechanical properties as those of the substrates, causing deformation or distortion and even detachment of the patterns from the polymer substrates. Herein, we prese...
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Open AccessWhole-exome sequencing identifies protein-coding variants associated with brain iron in 29,828 individuals
Iron plays a fundamental role in multiple brain disorders. However, the genetic underpinnings of brain iron and its implications for these disorders are still lacking. Here, we conduct an exome-wide associatio...
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Oriented R-CNN and Beyond
Currently, two-stage oriented detectors are superior to single-stage competitors in accuracy, but the step of generating oriented proposals is still time-consuming, thus hindering the inference speed. This pap...
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Open AccessA Cullin 5-based complex serves as an essential modulator of ORF9b stability in SARS-CoV-2 replication
The ORF9b protein, derived from the nucleocapsid’s open-reading frame in both SARS-CoV and SARS-CoV-2, serves as an accessory protein crucial for viral immune evasion by inhibiting the innate immune response. ...
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Low cost and low density chloride solid electrolyte for all solid state cathode with high active material ratio
Chloride solid electrolytes (SEs) have attracted widespread attention due to their high room-temperature ionic conductivity and excellent cathode compatibility. However, the conventionally selected central met...
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Open AccessCorrection: Gut microbiota-derived propionate mediates the neuroprotective effect of osteocalcin in a mouse model of Parkinson’s disease
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Open AccessZero-profile implant system versus novel plate systems after ACDF for comparison of sagittal balance parameters and clinical efficacy analysis
The zero-profile implant system (Zero-P) and conventional plates have been widely used in anterior cervical discectomy and fusion (ACDF) to treat cervical spondylosis. The purpose of this study was to compare ...
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Experimental quantum computational chemistry with optimized unitary coupled cluster ansatz
Quantum computational chemistry has emerged as a potential application of quantum computing. Hybrid quantum-classical computing methods, such as variational quantum eigensolvers, have been designed as promisin...
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Open AccessSilver coordination-induced n-do** of PCBM for stable and efficient inverted perovskite solar cells
The bidirectional migration of halides and silver causes irreversible chemical corrosion to the electrodes and perovskite layer, affecting long-term operation stability of perovskite solar cells. Here we propo...
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Large-scale foundation model on single-cell transcriptomics
Large pretrained models have become foundation models leading to breakthroughs in natural language processing and related fields. Develo** foundation models for deciphering the ‘languages’ of cells and facil...
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Open AccessGenome-wide analysis reveals genomic diversity and signatures of selection in Qinchuan beef cattle
Indigenous Chinese cattle have abundant genetic diversity and a long history of artificial selection, giving local breeds advantages in adaptability, forage tolerance and resistance. The detection of selective...
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Open AccessThe management pattern and outcomes of chronic thromboembolic pulmonary hypertension: rationale and design for a Chinese real-world study
Chronic thromboembolic pulmonary hypertension (CTEPH) is a progressive pulmonary vascular disorder with substantial morbidity and mortality, also a disease underdiagnosed and undertreated. It is potentially cu...
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Open AccessPPIA dictates NRF2 stability to promote lung cancer progression
Nuclear factor erythroid 2-related factor 2 (NRF2) hyperactivation has been established as an oncogenic driver in a variety of human cancers, including non-small cell lung cancer (NSCLC). However, despite mass...
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Probability Regarding the Tumor-Promoter Role of Porphyromonas gingivalis for the Gastric Carcinogenesis
