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  1. No Access

    Article

    Ketamine Self-Administration Elevates αCaMKII Autophosphorylation in Mood and Reward-Related Brain Regions in Rats

    Modulation of αCaMKII expression and phosphorylation is a feature shared by drugs of abuse with different mechanisms of action. Accordingly, we investigated whether αCaMKII expression and activation could be a...

    Lucia Caffino, Alessandro Piva, Francesca Mottarlini… in Molecular Neurobiology (2018)

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    Article

    Ketamine Self-Administration Reduces the Homeostasis of the Glutamate Synapse in the Rat Brain

    Ketamine is a non-competitive antagonist of the NMDA glutamate receptor with psychotomimetic and reinforcing properties, although recent work has pointed out its antidepressant action following acute exposure....

    Lucia Caffino, Alessandro Piva, Giuseppe Giannotti… in Molecular Neurobiology (2017)

  3. No Access

    Article

    The Cathinones MDPV and α-PVP Elicit Different Behavioral and Molecular Effects Following Acute Exposure

    Since the mid-to-late 2000s, synthetic cathinones have gained popularity among drug users due to their psychostimulant effects greater than those produced by cocaine and amphetamine. Among them, 3,4-methylened...

    Giuseppe Giannotti, Isabella Canazza, Lucia Caffino… in Neurotoxicity Research (2017)

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    Article

    Developmental Exposure to Cocaine Dynamically Dysregulates Cortical Arc/Arg3.1 Modulation in Response to a Challenge

    During adolescence, the medial prefrontal cortex (mPFC) is still develo**. We have previously shown that developmental cocaine exposure alters mPFC’s ability to cope with challenging events. In this manuscri...

    Lucia Caffino, Giuseppe Giannotti, Francesca Mottarlini… in Neurotoxicity Research (2017)

  5. No Access

    Article

    Long-Term Abstinence from Developmental Cocaine Exposure Alters Arc/Arg3.1 Modulation in the Rat Medial Prefrontal Cortex

    Cocaine is a psychostimulant whose abuse causes a social and economic burden for our society. Most of the published literature deals with acute effects of cocaine or short-term abstinence in adult animals but ...

    Lucia Caffino, Giuseppe Giannotti, Chiara Malpighi… in Neurotoxicity Research (2014)