40 Result(s)
within
Gioacchino Tedeschi
Neurosciences
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Article
Open AccessAltered domain-specific striatal functional connectivity in patients with Parkinson’s disease and urinary symptoms
In this study, we aimed at investigating the possible association of urinary symptoms with whole-brain MRI resting-state functional connectivity (FC) alterations from distinct striatal subregions in a large co...
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Evaluation of drivers of treatment switch in relapsing multiple sclerosis: a study from the Italian MS Registry
Active relapsing–remitting (RR) and secondary progressive (SP) multiple sclerosis (MS) are currently defined as “relapsing MS” (RMS). The aim of this cross-sectional study was to assess drivers of treatment sw...
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Article
Open AccessCOVID-19 outbreak in Italy: an opportunity to evaluate extended interval dosing of ocrelizumab in MS patients
During the COVID-19 pandemic, ocrelizumab (OCR) infusions for MS patients were often re-scheduled because of MS center's disruption and concerns regarding immunosuppression. The aim of the present study was to...
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Open AccessIntrinsic brain functional connectivity predicts treatment-related motor complications in early Parkinson’s disease patients
Treatment-related motor complications may develop progressively over the course of Parkinson’s disease (PD).
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Open AccessCorrection to: Resting-state functional MRI in multicenter studies on multiple sclerosis: a report on raw data quality and functional connectivity features from the Italian Neuroimaging Network Initiative
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Open AccessResting state fMRI analysis of pseudobulbar affect in Amyotrophic Lateral Sclerosis (ALS): motor dysfunction of emotional expression
Pseudobulbar affect (PBA), referring to exaggerated or inappropriate episodes of laughing and/or crying without an apparent motivating stimulus, has been mainly attributed to bilateral degeneration of corticob...
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Open AccessResting-state functional MRI in multicenter studies on multiple sclerosis: a report on raw data quality and functional connectivity features from the Italian Neuroimaging Network Initiative
The Italian Neuroimaging Network Initiative (INNI) is an expanding repository of brain MRI data from multiple sclerosis (MS) patients recruited at four Italian MRI research sites. We describe the raw data qual...
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Resting-state network connectivity changes in drug-naive Parkinson’s disease patients with probable REM sleep behavior disorder
Epidemiological studies have shown that Parkinson’s disease (PD) patients with probable REM sleep behavior disorder (pRBD) present an increased risk of worse cognitive progression over the disease course. The ...
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Multicenter data harmonization for regional brain atrophy and application in multiple sclerosis
In multiple sclerosis (MS), determination of regional brain atrophy is clinically relevant. However, analysis of large datasets is rare because of the increased variability in multicenter data.
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Open AccessHumoral response and safety of the third booster dose of BNT162b2 mRNA COVID-19 vaccine in patients with multiple sclerosis treated with ocrelizumab or fingolimod
The assessment of the safety and the humoral response to a third booster dose of the BNT162b2 mRNA COVID-19 vaccine is relevant in patients with Multiple Sclerosis (pwMS) treated with Ocrelizumab (OCR) or Fing...
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Open AccessCorrection to: Prevalence and predictors of bowel dysfunction in a large multiple sclerosis outpatient population: an Italian multicenter study
The original version of this article unfortunately contained a mistake. The given and family names of authors were Interchanged except the following author Maria Chiara Buscarinu, Carolina Gabri Nicoletti, Ale...
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Open AccessOpinion, knowledge, and clinical experience with functional neurological disorders among Italian neurologists: results from an online survey
Functional neurological disorders (FND) are disabling medical conditions commonly seen in neurological practice. Neurologists play an essential role in managing FND, from establishing a diagnosis to coordinati...
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Article
Open AccessBetween-sex variability of resting state functional brain networks in amyotrophic lateral sclerosis (ALS)
The organization of brain functional connectivity (FC) has been shown to differ between sexes. Amyotrophic lateral sclerosis (ALS) is characterized by sexual dimorphism, showing sex-specific trends in site of ...
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Open AccessCorrelates of the discrepancy between objective and subjective cognitive functioning in non-demented patients with Parkinson’s disease
Subjective complaints of cognitive deficits are not necessarily consistent with objective evidence of cognitive impairment in Parkinson’s disease (PD). Here we examined the factors associated with the objectiv...
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Open AccessHippocampal connectivity in Amyotrophic Lateral Sclerosis (ALS): more than Papez circuit impairment
Emerging evidence suggests that memory deficit in amyotrophic lateral sclerosis (ALS), a neurodegenerative disease with varying impairment of motor abilities and cognitive profile, may be independent from exec...
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Article
Unilateral polymicrogyria, hemispheric atrophy and spastic hemiparesis: rare etiologies for a common condition
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Co** strategies in relapsing–remitting multiple sclerosis non-depressed patients and their associations with disease activity
Few studies evaluated co** strategies in people with multiple sclerosis (pwMS) in relation to annualized relapse rate (ARR) and lesion load (LL). Overall, results might have been influenced by the inclusion ...
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A case of Cerebrotendinous Xanthomatosis with spinal cord involvement and without tendon xanthomas: identification of a new mutation of the CYP27A1 gene
Cerebrotendinous Xanthomatosis (CTX) is an autosomal recessive defect of the alternative pathway of bile acid biosynthesis, due to the deficiency of mitochondrial cytochrome P450 sterol 27-hydroxylase enzyme e...
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Open AccessPsychological consequences of COVID-19 pandemic in Italian MS patients: signs of resilience?
Anxiety, depression and reduction of quality of life (QoL) are common in people with multiple sclerosis (pwMS). Fear of getting sick from COVID-19, government’s lockdown and the imposed social distancing might...
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Supplementary motor area functional connectivity in “drug-naïve” Parkinson’s disease patients with fatigue
Fatigue is a common and disabling nonmotor manifestation in patients with Parkinson’s disease (PD), and the supplementary motor area (SMA) has been implicated in its pathophysiology. SMA is usually divided in ...
