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Open AccessAuthor Correction: The evolution of lung cancer and impact of subclonal selection in TRACERx
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Open AccessRepresentation of genomic intratumor heterogeneity in multi-region non-small cell lung cancer patient-derived xenograft models
Patient-derived xenograft (PDX) models are widely used in cancer research. To investigate the genomic fidelity of non-small cell lung cancer PDX models, we established 48 PDX models from 22 patients enrolled i...
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Article
Open AccessGenomic–transcriptomic evolution in lung cancer and metastasis
Intratumour heterogeneity (ITH) fuels lung cancer evolution, which leads to immune evasion and resistance to therapy1. Here, using paired whole-exome and RNA sequencing data, we investigate intratumour transcript...
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Article
Open AccessThe evolution of non-small cell lung cancer metastases in TRACERx
Metastatic disease is responsible for the majority of cancer-related deaths1. We report the longitudinal evolutionary analysis of 126 non-small cell lung cancer (NSCLC) tumours from 421 prospectively recruited pa...
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Article
Open AccessThe evolution of lung cancer and impact of subclonal selection in TRACERx
Lung cancer is the leading cause of cancer-associated mortality worldwide1. Here we analysed 1,644 tumour regions sampled at surgery or during follow-up from the first 421 patients with non-small cell lung cancer...
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Article
Open AccessAntibodies against endogenous retroviruses promote lung cancer immunotherapy
B cells are frequently found in the margins of solid tumours as organized follicles in ectopic lymphoid organs called tertiary lymphoid structures (TLS)1,2. Although TLS have been found to correlate with improved...
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Article
Pervasive chromosomal instability and karyotype order in tumour evolution
Chromosomal instability in cancer consists of dynamic changes to the number and structure of chromosomes1,2. The resulting diversity in somatic copy number alterations (SCNAs) may provide the variation necessary ...
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Publisher Correction: A clonal expression biomarker associates with lung cancer mortality
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Publisher Correction: Spatial heterogeneity of the T cell receptor repertoire reflects the mutational landscape in lung cancer
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
Publisher Correction: Pulmonary venous circulating tumor cell dissemination before tumor resection and disease relapse
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Article
The T cell differentiation landscape is shaped by tumour mutations in lung cancer
Tumour mutational burden (TMB) predicts immunotherapy outcome in non-small cell lung cancer (NSCLC), consistent with immune recognition of tumour neoantigens. However, persistent antigen exposure is detrimenta...
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Article
Interplay between whole-genome doubling and the accumulation of deleterious alterations in cancer evolution
Whole-genome doubling (WGD) is a prevalent event in cancer, involving a doubling of the entire chromosome complement. However, despite its prevalence and prognostic relevance, the evolutionary selection pressu...
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Article
Spatial heterogeneity of the T cell receptor repertoire reflects the mutational landscape in lung cancer
Somatic mutations together with immunoediting drive extensive heterogeneity within non-small-cell lung cancer (NSCLC). Herein we examine heterogeneity of the T cell antigen receptor (TCR) repertoire. The numbe...
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Article
A clonal expression biomarker associates with lung cancer mortality
An aim of molecular biomarkers is to stratify patients with cancer into disease subtypes predictive of outcome, improving diagnostic precision beyond clinical descriptors such as tumor stage1. Transcriptomic intr...
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Article
Pulmonary venous circulating tumor cell dissemination before tumor resection and disease relapse
Approximately 50% of patients with early-stage non-small-cell lung cancer (NSCLC) who undergo surgery with curative intent will relapse within 5 years1,2. Detection of circulating tumor cells (CTCs) at the time o...
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Article
Neoantigen-directed immune escape in lung cancer evolution
The interplay between an evolving cancer and a dynamic immune microenvironment remains unclear. Here we analyse 258 regions from 88 early-stage, untreated non-small-cell lung cancers using RNA sequencing and h...
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Computational Methods for Analysis of Tumor Clonality and Evolutionary History
Cancer is an evolutionary process. Recent advances in sequencing technologies have allowed us to investigate intratumor heterogeneity at the single nucleotide level. Here, we describe computational methods tha...
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Correction: Corrigendum: Phylogenetic ctDNA analysis depicts early-stage lung cancer evolution
Nature 545, 446–451 (2017); doi:10.1038/nature22364 For 6 of the 96 patients included in this Article (patients CRUK0014, CRUK0030, CRUK0048, CRUK0059, CRUK0096 and CRUK0097) incorrect tumour volumetric data a...
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Article
Evolution and clinical impact of co-occurring genetic alterations in advanced-stage EGFR-mutant lung cancers
Analysis of a large cohort of EGFR-mutant lung cancer cell-free DNA samples along with longitudinal samples from a patient with EGFR-mutant lung cancer identifies pathways that inhibit EGFR-inhibitor response. Co...
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Open AccessQuantification of tumour evolution and heterogeneity via Bayesian epiallele detection
Epigenetic heterogeneity within a tumour can play an important role in tumour evolution and the emergence of resistance to treatment. It is increasingly recognised that the study of DNA methylation (DNAm) patt...
