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Article
Open AccessA comprehensive workflow for optimizing RNA-seq data analysis
Current RNA-seq analysis software for RNA-seq data tends to use similar parameters across different species without considering species-specific differences. However, the suitability and accuracy of these tool...
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Article
Open AccessA study on the application of radiomics based on cardiac MR non-enhanced cine sequence in the early diagnosis of hypertensive heart disease
The prevalence of hypertensive heart disease (HHD) is high and there is currently no easy way to detect early HHD. Explore the application of radiomics using cardiac magnetic resonance (CMR) non-enhanced cine ...
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Article
Open AccessOptimization of preparation conditions and performance of a new degradable soil water retaining agent
Using polyaspartic acid (PAsp) and bentonite (BT) as the main raw materials, a new type of degradable soil water retaining agent (PAsp-AA/BT) was synthesized by microwave radiation. The optimum synthesis condi...
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Article
Open AccessMemory of elastic collisions drives high minority spin and oscillatory entropy in underdamped chiral spinners
Inertial underdamped collisions preserve the memory of physical parameters that existed before the collision, leading to phenomena usually unseen in overdamped systems. Here we probe the less studied inertial ...
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Article
Open AccessThe cavitation characteristics of aerospace high-speed centrifugal pumps with different tip clearance
This study investigates the Tip Clearance Cavitation (TCC) characteristics of three different Tip Clearances (TC) (0.4, 0.6, 0.8) and five inlet negative pressure conditions Pj = (− 20–60)kPa to improve the re...
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Article
Open AccessOxymatrine protects articular chondrocytes from IL-1β-induced damage through autophagy activation via AKT/mTOR signaling pathway inhibition
Osteoarthritis (OA) is a common degenerative joint disease characterized by persistent articular cartilage degeneration and synovitis. Oxymatrine (OMT) is a quinzolazine alkaloid extracted from the traditional...
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Article
Open AccessClinical evidence for efficacy of pembrolizumab in MSI-H and TMB-H advanced solid tumor: results from three cancer centers in China
Pembrolizumab has been indicated in the treatment of solid tumors with high frequency microsatellite instability (MSI-H) or high tumor mutational burden (TMB-H); however, real-world data on the effectiveness o...
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Article
Open AccessTh1 cells contribute to retinal ganglion cell loss in glaucoma in a VCAM-1-dependent manner
Glaucoma is a complex neurodegenerative disorder characterized by the progressive loss of retinal ganglion cells (RGC) and optic nerve axons, leading to irreversible visual impairment. Despite its clinical sig...
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Article
Open AccessInterplay between ATRX and IDH1 mutations governs innate immune responses in diffuse gliomas
Stimulating the innate immune system has been explored as a therapeutic option for the treatment of gliomas. Inactivating mutations in ATRX, defining molecular alterations in IDH-mutant astrocytomas, have been im...
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Article
Open AccessBiochemical and molecular characterization of a novel glycerol dehydratase from Klebsiella pneumoniae 2e with high tolerance against crude glycerol impurities
The direct bioconversion of crude glycerol, a byproduct of biodiesel production, into 1,3-propanediol by microbial fermentation constitutes a remarkably promising value-added applications. However, the low act...
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Article
Open AccessNomogram predicts risk of perineural invasion based on serum biomarkers for pancreatic cancer
Pancreatic cancer is a fatal tumor, and the status of perineural invasion (PNI) of pancreatic cancer was positively related to poor prognosis including overall survival and recurrence-free survival. This study...
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Article
Open AccessMetabolomics profiling in predicting of post-herpetic neuralgia induced by varicella zoster
To explore potential metabolomics biomarkers in predicting post-herpetic neuralgia (PHN) induced by herpes zoster (HZ). A total of 90 eligible patients were prospectively enrolled and assigned into an acute pa...
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Article
Open AccessCausal associations between gut microbiota and urological tumors: a two-sample mendelian randomization study
Dysbiosis of gut microbiota has been linked to numerous diseases, including cancer. The unique role of gut microbiota in urological tumors is gaining prominence. However, it is still controversial whether the ...
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Article
Open AccessDetection of Cd2+ based on Nano-Fe3O4/MoS2/Nafion/GCE sensor
It is necessary to detect cadmium ions in seawater with high sensitivity because the pollution of cadmium ions seriously endangers the health and life of human beings. Nano-Fe3O4/MoS2/Nafion modified glassy carbo...
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Article
Open AccessThe correlation of two bone turnover markers with bone mineral density: a population-based cross-sectional study
Exploring the correlation between bone turnover marks (BTMs) with lumbar BMD in middle-aged populations.
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Article
Open AccessSexually dimorphic methylation patterns characterize the placenta and blood from extremely preterm newborns
Health outcomes among children born prematurely are known to be sexually dimorphic, with male infants often more affected, yet the mechanism behind this observation is not clear. CpG methylation levels in the ...
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Article
Open AccessEthnicity-specific association between TERT rs2736100 (A > C) polymorphism and lung cancer risk: a comprehensive meta-analysis
The rs2736100 (A > C) polymorphism of the second intron of Telomerase reverse transcriptase (TERT) has been confirmed to be closely associated with the risk of Lung cancer (LC), but there is still no unified conc...
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Article
Open AccessGuidance for dysmorphic sacrum fixation with upper sacroiliac screw based on imaging anatomy study: techniques and indications
This study aimed to investigate the techniques and indications of upper sacroiliac screw fixation for the dysmorphic sacrum.
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Article
Open AccessComparison of multiple imputation and other methods for the analysis of imputed genotypes
Analysis of imputed genotypes is an important and routine component of genome-wide association studies and the increasing size of imputation reference panels has facilitated the ability to impute and test low-...
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Article
Open AccessNovel characteristics for immunophenotype, FISH pattern and molecular cytogenetics in synovial sarcoma
As a rare and highly aggressive soft tissue sarcoma, the new immunophenotype, atypical FISH pattern and relevant molecular cytogenetics of synovial sarcoma (SS) remain less known, although it is characteristic...
