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Article
FXR activation remodels hepatic and intestinal transcriptional landscapes in metabolic dysfunction-associated steatohepatitis
The escalating obesity epidemic and aging population have propelled metabolic dysfunction-associated steatohepatitis (MASH) to the forefront of public health concerns. The activation of FXR shows promise to co...
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Article
Genomic study of PIFs in cotton and functional analysis of GhPIF4 in promoting cotton flowering
Cotton is the most important commercial crop in the production of fiber for the textile industry worldwide, and flowering time is an important agronomic trait for cotton production. Phytochrome interacting fac...
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Article
A systematic review of fuzzing
Fuzzing is an important technique in software and security testing that involves continuously generating a large number of test cases against target programs to discover unexpected behaviors such as bugs, cras...
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Article
Migration behavior of solid fuel particles during granulation process and its influence on combustion property
Iron ore sintering process is the main CO2 emission source throughout the integrate steelworks, which primarily comes from the combustion of solid fuels. Improving the combustion efficiency and reducing the solid...
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Article
Ultra-high-depth macrogenomic sequencing revealed differences in microbial composition and function between high temperature and medium–high temperature Daqu
Complex microorganisms in Daqu of different temperatures play a vital role in the taste, flavor and quality of Baijiu during fermentation. However, understanding the functional diversity of the whole microbial co...
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Article
Open AccessCorrelation between abnormal energy metabolism of ovarian granulosa cells and in vitro fertilization–embryo transfer outcomes in patients with polycystic ovary syndrome and obesity
Granulosa cells (GCs) that surround oocytes in mammalian reproduction play an active role in oocyte differentiation through proliferation and energy production.
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Article
Critical role of PAFR/YAP1 positive feedback loop in cardiac fibrosis
Aberrant activation of cardiac fibroblasts is the main cause and character of cardiac fibrosis, and inhibition of cardiac fibrosis becomes a promising treatment for cardiac diseases. Platelet-activating factor...
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Chapter and Conference Paper
An Improved DDoS Attack Detection Model Based on Unsupervised Learning in Smart Grid
The bidirectional communication system in smart grid is vulnerable to distributed denial of service (DDoS) attacks, due to its characteristics of complex system structure and difficult to control. The multiple...
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Article
Double mutation of two homologous genes YL1 and YL2 results in a leaf yellowing phenotype in soybean [Glycine max (L.) Merr]
Two homologous, chloroplast located CAAX proteases were identified to be functional redundancy in determining soybean leaf color, and they probably play essential roles in regulating light harvesting and absor...
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Article
Open AccessMYB44 competitively inhibits the formation of the MYB340-bHLH2-NAC56 complex to regulate anthocyanin biosynthesis in purple-fleshed sweet potato
Anthocyanins, which have important biological functions and have a beneficial effect on human health, notably account for pigmentation in purple-fleshed sweet potato tuberous roots. Individual regulatory facto...
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Article
Source Tracking and Risk Assessment of Pharmaceutical and Personal Care Products in Surface Waters of Qingdao, China, with Emphasis on Influence of Animal Farming in Rural Areas
The occurrence and potential sources of pharmaceuticals and personal care products (PPCPs) in surface waters from a large coastal city Qingdao, North China, were investigated. Forty-five compounds were analyze...
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Article
Open AccessAssociation of genetic and immuno-characteristics with clinical outcomes in patients with RET-rearranged non-small cell lung cancer: a retrospective multicenter study
Rearranged during transfection (RET) has been proven to be a tumorigenic target in non-small cell lung cancers (NSCLCs). In RET-rearranged NSCLCs, molecular features and their impact on prognosis were not well il...
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Article
Small molecule IVQ, as a prodrug of gluconeogenesis inhibitor QVO, efficiently ameliorates glucose homeostasis in type 2 diabetic mice
Gluconeogenesis is a major source of hyperglycemia in patients with type 2 diabetes mellitus (T2DM), thus targeting gluconeogenesis to suppress glucose production is a promising strategy for anti-T2DM drug dis...
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Article
Open AccessMechanism of the JAK2/STAT3-CAV-1-NR2B signaling pathway in painful diabetic neuropathy
The aim of the present study was to further elucidate the role of JAK2/STAT3-CAV-1-NR2B on painful diabetic neuropathy.
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Article
Biological and Morphological Features Associated with English Grain Aphid and Bird Cherry-Oat Aphid Tolerance in Winter Wheat Line XN98-10-35
The English grain aphid, Sitobion avenae Fabricius (Hemiptera: Aphididae), and bird cherry-oat aphid, Rhopalosiphum padi L. (Hemiptera: Aphididae), are two common herbivore pests that have devastating effects on ...
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Article
A new monarch butterfly optimization with an improved crossover operator
Recently, by examining and simulating the migration behavior of monarch butterflies in nature, Wang et al. proposed a new swarm intelligence-based metaheuristic algorithm, called monarch butterfly optimization...
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Article
Identifying QTL–allele system of seed protein content in Chinese soybean landraces for population differentiation studies and optimal cross predictions
Soybean originated in ancient China has been quickly extended globally as a major protein and oil crop. The QTL–allele constitution of seed protein content (SPC) in the Chinese soybean landrace population (CSL...
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Article
Open AccessMiRNA-seq-based profiles of miRNAs in mulberry phloem sap provide insight into the pathogenic mechanisms of mulberry yellow dwarf disease
A wide range of miRNAs have been identified as phloem-mobile molecules that play important roles in coordinating plant development and physiology. Phytoplasmas are associated with hundreds of plant diseases, a...
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Article
An innovative procedure of genome-wide association analysis fits studies on germplasm population and plant breeding
The innovative RTM-GWAS procedure provides a relatively thorough detection of QTL and their multiple alleles for germplasm population characterization, gene network identification, and genomic ...
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Article
Open AccessDynamic Changes in the Splenic Transcriptome of Chickens during the Early Infection and Progress of Marek’s Disease
Gallid alphaherpesvirus 2 (GaHV2) is an oncogenic avian herpesvirus inducing Marek’s disease (MD) and rapid-onset T-cell lymphomas. To reveal molecular events in MD pathogenesis and tumor...
