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  1. Article

    Positional Specificity of Phosphatide Acyl Hydrolase (Phospholipase A)

    SNAKE venom phospholipase A was shown by de Haas and van Deenen to release the fatty acid constituent present in the β-ester position of mixed-acid phospholipids obtained by a synthesis de novo1–3. This result co...

    G. H. DE HAAS, F. J. M. DAEMEN, L. L. M. VAN DEENEN in Nature (1962)

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  2. Article

    Chemical Structure and Serological Activity of Synthetic and Natural Cardiolipin

    CARDIOLIPIN was first isolated by Pangborn1 from ox-heart and this compound proved to be the essential lipid of the antigen in the serodiagnosis of syphilis. Based on hydrolysis investigations, Macfarlane et al.2...

    G. H. DE HAAS, L. L. M. VAN DEENEN in Nature (1965)

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    Chapter

    Regulation of Pancreatic Phospholipase A2 Activity by Different Lipid-Water Interfaces

    Pancreatic phospholipase A2 interacts with lipid-water interfaces by means of a specific region, the Interface Recognition Site (IRS), which most probably penetrates to a certain extent into the hydrophobic inter...

    M. C. E. van Dam-Mieras, A. J. Slotboom, H. M. Verheij… in Structure of Biological Membranes (1977)

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    Chapter

    Relationship between Structure and Activity of Pancreatic Phospholipase A2

    Phospholipase A2 (EC 3.1.1.4) hydrolyzes exclusively the 2­acyl ester linkage of all types of naturally occurring phosphogly­cerides (1). The enzyme acts highly stereospecific and only 3-sn­phosphoglycerides are ...

    A. J. Slotboom, M. C. E. van Dam-Mieras, E. H. J. M. Jansen… in Enzymes of Lipid Metabolism (1978)

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    Chapter

    Phospholipase A2 Interaction with Various Phospholipids. A Model for the Lipoprotein Molecule?

    This NATO-workshop is devoted to the structure and function of the lipoprotein molecule. Important building stones of these complexes are the so-called“apoproteins” and phospholipids. Considerable progress has...

    G. H. de Haas, A. J. Slotboom, H. M. Verheij, J. C. Vidal… in The Lipoprotein Molecule (1978)

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    Chapter

    Studies of Lipase and Phospholipase A2 Acting on Lipid Monolayers

    Le phénomène de la pénétration dans des films lipidiques mono-moléculaires de différents enzymes lipolytiques a été étudié grâce à la méthode du barostat superficiel. Le temps d’induction, mesuré durant l’état...

    R. Verger, J. Rietsch, F. Pattus, F. Ferrato, G. Pieroni… in Enzymes of Lipid Metabolism (1978)

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    Article

    Does a chemically symmetric bond pattern induce a symmetric conformation of lecithin molecules in membranes?

    G. Büldt, G. H. de Haas, J. Seelig in Biophysics of structure and mechanism (1980)

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    Article

    Association of lysophosphatidylcholine with fatty acids in aqueous phase to form bilayers

    Lysophospholipids have been implicated in a variety of physiological processes1. In vivo lysophospholipids are invariably produced with fatty acids as the product of hydrolysis by phospholipase A2 (ref. 2). There...

    M. K. Jain,  C. J. A. van Echteld,  F. Ramirez,  J. de Gier,  G. H. de Haas… in Nature (1980)

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    Chapter

    Structure and function of phospholiphase A2

    H. M. Verheij, A. J. Slotboom, G. H. de Haas in Reviews of Physiology, Biochemistry and Ph… (1981)

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    Chapter

    The Interaction of Pancreatic Phospholipase A2 with Negatively Charged Substrates — Application: The Transformation of Soluble Phospholipase A2 into a Highly Penetrating “Membrane-Bound” Form

    This study deals with some kinetic properties of porcine pancreatic phospholipase A2 (PLA2) acting on neutral and anionic substrates. Short—chain diacylglycerosulfates possess a much higher affinity to the enzyme...

    G. H. de Haas, A. J. Slotboom, M. G. van Oort… in Enzymes of Lipid Metabolism II (1986)

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    Chapter

    Probing the Mechanism of Pancreatic Phospholipase A2 with the Aid of Recombinant DNA Techniques

    Phospholipase A2 (E.C. 3.1.1.4) attacks the acyl ester bond at position 2 of 3-sn-phosphoglycerides (van Deenen en de Haas, 1963). The in-vivo importance of phospholipase A2 (PLA) is reflected by the fact that th...

    O. P. Kuipers, C. J. van den Bergh… in Biochemistry, Molecular Biology, and Physi… (1990)

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    Article

    Solution structure of porcine pancreatic phospholipase A2 complexed with micelles and a competitive inhibitor

    The three-dimensional structure of porcine pancreatic PLA2 (PLA2), present in a 40 kDa ternary complex with micelles and a competitive inhibitor, has been determined using multidimensional heteronuclear NMR spect...

    B. van den Berg, M. Tessari, R. Boelens, R. Dijkman… in Journal of Biomolecular NMR (1995)