14 Result(s)
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Chapter
Acute Cyclosporine a Nephrotoxicity
Experimental studies in rats have demonstrated that CyA causes tubular necrosis only when given at very high dosage. At a dosage of 20 mg/kg b.w./day proximal tubular changes are subtle and can be detected onl...
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Chapter
Successfull Treatment with Bicarbonate Dialysis (BD) of Severe Lactic Acidosis in Phenformin Treated Patients on Dialytic Treatment (DT)
Phenformin is a well recognized cause of lactic acidosis (1.2) : for this reason, the health authorities of many Countries have withdrawn this drug: for istance, in the U.S.A. this is not available since 1977....
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Chapter
Effects of Cyclosporine a on Renal Function and Proteinuria in Patients with Nephrotic Syndrome after a Single Oral Administration
Cyclosporine A (CyA) is probably the most important advance in the immunosuppressive management of transplants, reducing the incidence of acute rejections without relevant incidence of haematologic and infecti...
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Chapter
Is Tubulointerstitial Damage a Reliable Index for Predicting Renal Outcome in Primary Membranous Nephropathy?
Interstitial changes are often observed in primary glomerular disease. However, the severity of these changes is not always mirrored by the glomerular involvement. Aim of this study is to evaluate if the prese...
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Chapter
“Renal Functional Reserve” in Renal Transplant Patients on Cyclosporine Therapy
The increase in glomerular filtration rate (GFR) due to afferent and efferent arterioles vasodilation induced by protein-load or aminoacids and/or dopamine is termed “Renal Functional Reserve” (R...
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Chapter
Clinical Presentation of IgA Nephropathy in Southern Italy
First discovered by Berger (1–2), primary IgA nephropathy has been recognized as a distinct glomerulonephritis and defined as a disease with prominent mesangial IgA deposits in the absence of clinical signs of...
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Chapter
Relation Between Gengival Overgrowth and Cyclosporin (CyA) Blood Levels in Renal Transplanted Patients
Gengival hypertrophy has been associated with the use of several drugs (phenytoin, primidone, valproic acid, nifedipine, nicardipine et al). Recently also CyA has been reported to cause this side effect. The m...
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Chapter
A Case of Relapsing Renal Micropolyarteritis: A Possible Association with Assumption of non Steroidal Antiinflammatory Drugs (NSAID)
The onset of renal micropolyarteritis has been associated with the administration of a number of drugs: penicillins, suiphonamides and phenytoin have been more frequently recorded. The relationship between NSA...
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Chapter
Renal Presentation is Not a Relevant Factor in Predicting Renal Outcome in Patients with Systemic Lupus
Lupus nephritis is the most important cause of death in patients with systemic lupus erythematous (1–4). For this reason, an early biologic and clinic evaluation could be of great prognostic rilevance.
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Chapter
Cyclosporine a Nephrotoxicity
Despite the many studies performed both in humans and in experimental animals during the decade which has elapsed since the introduction of Cyclosporine A (CyA) into clinical practice, the mechanisms by which ...
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Chapter
Renal Hemodynamic Effects of Short-Term Therapy with Low Doses of Cyclosporine a in Humans with Intact Kidneys
Extensive studies in humans and in laboratory animals on acute cyclosporine A (CsA) nephrotoxicity have demonstrated that the decrease of GFR induced by CsA is due to a direct, although reversible impairment o...
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Chapter
Modifications of Plasma Volume and ANF During Long-Term Administration of Cyclosporie
It has been recently suggested that prolonged administration of Cyclosporine (CsA) may determine a reduction of plasma volume (PV), potentially responsible for the nephrotoxicity induced by the drug ([1]). Aim...
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Chapter
Early Effects of Acute Obstruction of Biliary Duct in the Rat
The effects of jaundice on renal function have been until now studied in experimental models after 10–14 days or more of common bile duct ligation (1): this time of obstruction was sufficient to induce not onl...
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Chapter
Urinary Tract Infections in Pregnancy
Urinary tract infection (UTI) is a common problem, affecting an estimated 10% to 20% of women during their lifetime (1). Consequently, it is not surprising that UTI represents one of the most common complicati...
